Evaluation of quality control procedures in an oesophageal cancer cohort study in Anyang, China
Evaluation of quality control procedures in an oesophageal cancer cohort study in Anyang, China
复制标题
中国安阳食管癌队列研究的质量控制程序评估。
DOI：
10.1016/j.jhin.2010.06.005
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发表时间：
2010-12-01
影响因子：
6.9
通讯作者：
Ke, Y.
中科院分区：
文献类型：
--
作者：
He, Z.;Chen, K.;Ke, Y.
我们希望评估一项队列研究的内部质量控制程序的效率，该研究调查了人乳头瘤病毒（HPV）感染作为中国安阳食管癌的关键暴露因素。通过在样本采集设备上对来自14个位点的2395份环境/设备拭子和模拟质控样本进行人β-珠蛋白和HPV DNA检测来完成。人类β-珠蛋白存在于这些样本的3.88%，但没有检测到HPV DNA。在我们正在进行的队列研究中，在严格的质量控制下，没有证据表明样本采集或处理中存在HPV DNA污染。研究结果表明，使用一次性器具，严格的环境清洁和可重复使用的器械的高标准灭菌在防止污染方面非常重要。(C)2010年，医院感染协会。由爱思唯尔有限公司出版。保留所有权利。
We wished to evaluate the efficiency of internal quality control procedures of a cohort study investigating human papilloma virus (HPV) infection as a key exposure factor in oesophageal cancer in Anyang, China. This was done by testing 2395 environmental/equipment swab and mock quality control samples from 14 loci on sample collection equipment for human beta-globin and HPV DNA. Human beta-globin was present in 3.88% of these samples but no HPV DNA was detected. There was no evidence of HPV DNA contamination in the sample collection or processing under the rigorous quality control in our ongoing cohort study. The study results indicated that use of disposable appliances, rigorous environmental cleaning and a high standard of sterilisation of reusable instruments are important in contamination prevention. (C) 2010 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.