Jet fuel exposure and auditory outcomes in Australian air force personnel
Jet fuel exposure and auditory outcomes in Australian air force personnel
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DOI：
10.1186/s12889-019-7038-0
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发表时间：
2019-05-31
影响因子：
4.5
通讯作者：
Fuentes-Lopez, Eduardo
中科院分区：
文献类型：
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作者：
Fuente, Adrian;Hickson, Louise;Fuentes-Lopez, Eduardo
背景：动物数据表明，喷气燃料（如JP-8）与噪音结合时与听力缺陷有关，其影响比单独接触噪音更为明显。一些研究认为是外周功能障碍，而另一些研究认为是中枢性听觉障碍。在这方面，人类数据有限。本研究的目的是探讨JP-8结合噪声暴露对人类外周和中枢听觉系统可能产生的慢性不良影响。方法：选取57名澳大利亚皇家空军现役人员作为研究对象。根据他们对航空燃料的暴露程度，参与者被分为三个暴露组（低、中、高）。各组也根据噪音暴露水平（低、中、高）进行分类。对所有被试进行中音测量、纯音测听（1-12kHz）、失真产物耳声发射（dpoae）、听觉脑干反应（ABR）、噪声词、压缩语音、二位数测试、音高模式序列测试、持续模式序列测试和时间分辨率自适应测试。所有的听觉测试都是在参与者离开空军基地至少两周后进行的，因此两周内没有喷气燃料和噪音。结果：喷气燃料暴露与4和8kHz的听力阈值显著相关；较好的耳朵各频率的平均听力阈值；2.8、4、6kHz的dpoae；右耳ABR波V潜伏期；压缩语音和噪音中的单词。进一步的分析表明，与中等和高暴露水平的参与者相比，低暴露水平的参与者在上述程序中表现出明显更好的结果。所有结果都控制了年龄和噪声暴露水平的协变量。结论：结果表明，喷气燃料暴露，当与噪音暴露相结合时，对人类的听力有不利影响。考虑到所有的测试结果，喷气燃料暴露和噪音暴露似乎特别影响人类的外周听力系统。
Background: Animal data suggest that jet fuels such as JP-8 are associated with hearing deficits when combined with noise and that the effect is more pronounced than with noise exposure alone. Some studies suggest peripheral dysfunction while others suggest central auditory dysfunction. Human data are limited in this regard. The aim of this study was to investigate the possible chronic adverse effects of JP-8 combined with noise exposure on the peripheral and central auditory systems in humans.Methods: Fifty-seven participants who were current personnel from the Royal Australian Air Force were selected. Based on their levels of exposure to jet fuels, participants were divided into three exposure groups (low, moderate, high). Groups were also categorised based on their noise exposure levels (low, moderate, high). All participants were evaluated by tympanometry, pure-tone audiometry (1-12kHz), distortion product otoacoustic emissions (DPOAEs), auditory brainstem response (ABR), words-in-noise, compressed speech, dichotic digit test, pitch pattern sequence test, duration pattern sequence test and adaptive test of temporal resolution. All auditory tests were carried out after the participants were away from the Air Force base for a minimum of two weeks, thus two weeks without jet fuel and noise exposure.Results: Jet fuel exposure was significantly associated with hearing thresholds at 4 and 8kHz; average hearing thresholds across frequencies in the better ear; DPOAEs at 2.8, 4 and 6kHz; ABR wave V latency in the right ear; compressed speech and words-in-noise. Further analyses revealed that participants with low exposure level to jet fuels showed significantly better results for the aforementioned procedures than participants with moderate and high exposure levels. All results were controlled for the covariates of age and noise exposure levels.Conclusions: The results suggest that jet fuel exposure, when combined with noise exposure, has an adverse effect on audibility in humans. Taking all the test results into consideration, jet fuel exposure combined with noise exposure specifically seems to affect the peripheral hearing system in humans.