DC vaccine generated by ALA-PDT-induced immunogenic apoptotic cells for skin squamous cell carcinoma.
DC vaccine generated by ALA-PDT-induced immunogenic apoptotic cells for skin squamous cell carcinoma.
复制标题
ALA-PDT诱导免疫原性凋亡细胞产生的皮肤鳞状细胞癌DC疫苗
DOI：
10.1080/2162402x.2015.1072674
复制
发表时间：
2016-06
期刊：
影响因子：
7.2
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Ji J;Zhang Y;Chen WR;Wang X
树突状细胞（DC）疫苗是由5-氨基乙酰丙酸（ALA）介导的光动力疗法（PDT）诱导凋亡的鳞状细胞癌（SCC）细胞制备的。ALA-PDT-DC疫苗抑制小鼠SCC的生长，表明免疫原性凋亡细胞可以激活有效的抗肿瘤适应性免疫，从而导致基于DC疫苗的癌症免疫治疗。
ABSTRACT Dendritic cell (DC) vaccines were generated by apoptotic squamous cell carcinoma (SCC) cells induced by 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT). ALA-PDT-DC vaccine inhibited the growth of SCC in mice, indicating that immunogenic apoptotic cells can activate an effective antitumor adaptive immunity and lead to a DC vaccine-based cancer immunotherapy.