Can finite element models of ballooning procedures yield mechanical response of the cardiovascular site to overexpansion?
Can finite element models of ballooning procedures yield mechanical response of the cardiovascular site to overexpansion?
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DOI：
10.1016/j.jbiomech.2016.06.021
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发表时间：
2016-09-06
影响因子：
2.4
通讯作者：
Schievano S
中科院分区：
文献类型：
--
作者：
Bosi GM;Biffi B;Biglino G;Lintas V;Jones R;Tzamtzis S;Burriesci G;Migliavacca F;Khambadkone S;Taylor AM;Schievano S
患者特定的数值模型可以帮助经皮瓣膜选择的决策过程;为了提供充分的信息，它们应包括植入部位解剖结构和力学的患者特定数据。该信息可以从心动周期期间的常规临床成像中获得，但植入部位对器械扩张的机械反应数据通常不可用。我们的目标是通过监测球囊尺寸测量过程中的压力/尺寸变化以及使用经验证的计算球囊模型应用逆向工程方法来推导植入部位对过度扩张的反应。本研究提出了这种计算框架在体外测试的概念证明。使用PTS-X405测量球囊（NuMed，Inc.，USA），并根据在特设实验装置上进行的台架试验进行了验证：第一次单独使用球囊以复制自由扩张;第二次使用被认为适用于复制肺动脉的材料在快速原型圆柱体中充盈球囊，以验证球囊/植入部位相互作用算法。最后，在顺应性快速原型患者特定的右心室流出道内充盈球囊，以测试该方法的有效性。建立了相应的有限元模拟，以迭代地推断解剖模型的力学响应。在这种简化条件下进行的测试证实了所提出方法的可行性以及该方法在过度扩张时提供植入部位机械反应的患者特定信息的潜力，最终在患者特定环境中进行更真实的计算模拟。
Patient-specific numerical models could aid the decision-making process for percutaneous valve selection; in order to be fully informative, they should include patient-specific data of both anatomy and mechanics of the implantation site. This information can be derived from routine clinical imaging during the cardiac cycle, but data on the implantation site mechanical response to device expansion are not routinely available. We aim to derive the implantation site response to overexpansion by monitoring pressure/dimensional changes during balloon sizing procedures and by applying a reverse engineering approach using a validated computational balloon model. This study presents the proof of concept for such computational framework tested in-vitro. A finite element (FE) model of a PTS-X405 sizing balloon (NuMed, Inc., USA) was created and validated against bench tests carried out on an ad hoc experimental apparatus: first on the balloon alone to replicate free expansion; second on the inflation of the balloon in a rapid prototyped cylinder with material deemed suitable for replicating pulmonary arteries in order to validate balloon/implantation site interaction algorithm. Finally, the balloon was inflated inside a compliant rapid prototyped patient-specific right ventricular outflow tract to test the validity of the approach. The corresponding FE simulation was set up to iteratively infer the mechanical response of the anatomical model. The test in this simplified condition confirmed the feasibility of the proposed approach and the potential for this methodology to provide patient-specific information on mechanical response of the implantation site when overexpanded, ultimately for more realistic computational simulations in patient-specific settings.
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DOI：
10.1080/10255842.2011.641123
发表时间：
2013-08-01
影响因子：
1.6
作者：
Garcia-Herrera, Claudio M.;Celentano, Diego J.;Cruchaga, Marcela A.
通讯作者：
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影响因子：
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作者：
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影响因子：
2
作者：
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通讯作者：
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影响因子：
2.4
作者：
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通讯作者：
Holzapfel, GA
DOI：
10.1016/s0045-7825(00)00323-6
发表时间：
2001-01-01
影响因子：
7.2
作者：
Holzapfel, GA;Gasser, TC
通讯作者：
Gasser, TC