Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).
Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).
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DOI：
10.1016/j.pmedr.2016.06.013
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发表时间：
2016-12
影响因子：
2.8
通讯作者：
SESSA Research Group
中科院分区：
文献类型：
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作者：
Fujiyoshi A;Miura K;Kadowaki S;Azuma K;Tanaka S;Hisamatsu T;Arima H;Kadota A;Miyagawa N;Takashima N;Ohkubo T;Saitoh Y;Torii S;Miyazawa I;Maegawa H;Murata K;Ueshima H;SESSA Research Group
来自西方国家的研究表明，吸烟者往往比不吸烟者表现出更大的腹部肥胖，尽管他们的体重较低。这一点在较瘦的人口中是否成立，需要澄清。使用包括内脏脂肪组织在内的腹部肥胖指数，我们检查了终生吸烟是否与日本男性中不利的脂肪分布有关。2006年至2008年，我们对40-年龄段、无心血管疾病和癌症的日本男性进行了横断面调查。用CT计算腹部内脏脂肪组织(VAT)和皮下脂肪组织(SAT)的面积。我们将参与者分为四组：从不吸烟者和吸烟者吸烟三年。采用多元线性回归方法，计算每组肥胖指数的调整平均数(VAT、SAT、VAT-SAT比率[VSR]、腰臀比[WHR])，并计算连续组间的平均差异。我们分析了513名男性(年龄中值，58.2岁；目前吸烟者，40.1%)。三分之二的人显示身体质量指数(BMI)为25千克/平方米(中位数为23.5千克/平方米)。总体而言，终生吸烟组与更高的腰臀比和VSR相关。平均而言，在调整了包括体重指数在内的潜在混杂因素后，吸烟人数增加一个组，腰围比增加0.005(95%CI，0.001-0.008；P=0.005)，VSR增加0.041(95%CI，0.009-0.073；P=0.012)。在这个相对苗条的日本男性样本中，终生吸烟越多，代谢越不利的脂肪分布越多。虽然吸烟通常与较低的BMI有关，但应提倡减少终生吸烟量。吸烟者往往比不吸烟者有更大的腹部肥胖症。我们对日本男性的瘦身人群样本进行了研究。结果包括腰臀比(WHR)和内脏-皮下面积比(VSR)。终生吸烟越多，腰围比和VSR越高。
Studies from Western countries suggest that smokers tend to display greater abdominal obesity than non-smokers, despite showing lower weight. Whether this holds true in a leaner population requires clarification. Using indices of abdominal obesity including visceral adipose tissue, we examined whether lifetime cigarette smoking is associated with unfavorable fat distribution among Japanese men. From 2006 to 2008, we conducted a cross-sectional investigation of a community-based sample of Japanese men at 40–64 years old, free of cardiovascular diseases and cancer. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography. We divided participants into four groups: never-smokers; and tertiles of pack-years of smoking among ever-smokers. Using multivariable linear regression, we calculated adjusted means of obesity indices (VAT, SAT, VAT-SAT ratio [VSR], and waist-hip ratio [WHR]) for each group, and mean differences between consecutive groups. We analyzed 513 men (median age, 58.2 years; current smokers, 40.1%). Two-thirds showed body mass index (BMI) < 25 kg/m2 (median, 23.5 kg/m2). Overall, greater lifetime smoking group was associated with greater WHR and VSR. On average, one higher smoking group was associated with 0.005 higher WHR (95% CI, 0.001–0.008; P = 0.005) and 0.041 greater VSR (95% CI, 0.009–0.073; P = 0.012) after adjustment for potential confounders, including BMI. In this sample of relatively lean Japanese men, greater lifetime smoking was associated with a metabolically more adverse fat distribution. Although smoking is commonly associated with lower BMI, minimizing the amount of lifetime smoking should be advocated. Smokers tend to have greater abdominal obesity than non-smokers. We explored the relationship on a lean population-sample of Japanese men. Outcomes include waist-hip ratio (WHR) and visceral-subcutaneous area ratio (VSR). Greater lifetime smoking was associated with greater WHR and VSR.