Atopic phenotype is an important determinant of immunoglobulin E-mediated inflammation and expression of T helper cell type 2 cytokines to Ascaris antigens in children exposed to ascariasis
Atopic phenotype is an important determinant of immunoglobulin E-mediated inflammation and expression of T helper cell type 2 cytokines to Ascaris antigens in children exposed to ascariasis
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DOI：
10.1086/423944
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发表时间：
2004-10-01
影响因子：
6.4
通讯作者：
Nutman, TB
中科院分区：
文献类型：
--
作者：
Cooper, PJ;Chico, ME;Nutman, TB
研究表明特应性和土蠕虫感染之间存在很强的负相关关系，表明特应性可以预防土蠕虫感染。特应性个体对蛔虫病的抵抗可能是通过增强免疫球蛋白 E 介导的反应和 2 型辅助 T 细胞 (Th2) 细胞因子对寄生虫抗原的表达来实现的。为了研究特应性对蛔虫抗原免疫反应的影响，从厄瓜多尔农村学校招募了学龄儿童。比较按特应性和/或蚓螈感染状态分层的儿童之间的免疫学变量；这些变量包括外周血单核细胞（PBMC）的细胞因子表达和响应蛔虫抗原而释放的组胺。与非特应性儿童相比，特应性儿童的 PBMC 表达白细胞介素 (IL)-4 和 IL-5 的频率更高，组胺释放也增强。按特应性和蛔虫感染状态进行分层显示，特应性、未感染儿童的组胺和 Th2 细胞因子反应最强。多变量回归分析显示特应性状态对 Th2 细胞因子表达和组胺释放有显着影响，但感染状态没有显着影响。
Studies have shown a strong inverse relationship between atopy and geohelminth infection, indicating that atopy may protect against geohelminth infection. Resistance to ascariasis in atopic individuals may occur through greater immunoglobulin E-mediated responses and expression of T helper cell type 2 (Th2) cytokines to parasite antigens. To investigate the effect that atopy has on the immune response to Ascaris antigens, school-age children were recruited from rural schools in Ecuador. Immunologic variables were compared between children stratified by atopic and/or A. lumbricoides-infection status; the variables included cytokine expression by peripheral-blood mononuclear cells (PBMCs) and histamine release in response to Ascaris antigens. Atopic children had both greater frequencies of PBMCs expressing interleukin (IL)-4 and IL-5 and enhanced histamine release, compared with those in nonatopic children. Stratification by atopic and A. lumbricoides-infection status revealed the greatest histamine and Th2 cytokine responses in the stratum of atopic, noninfected children. Multivariate regression analyses showed significant effects for atopic status but not for infection status on Th2 cytokine expression and histamine release.