NEONATAL POPULATION PHARMACOKINETICS OF PHENOBARBITAL DERIVED FROM ROUTINE CLINICAL-DATA
NEONATAL POPULATION PHARMACOKINETICS OF PHENOBARBITAL DERIVED FROM ROUTINE CLINICAL-DATA
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DOI：
10.1159/000457062
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
DONN, SM
中科院分区：
文献类型：
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作者：
GRASELA, TH;DONN, SM
对59例接受苯巴比妥治疗的早产儿的常规临床药代动力学（PK）数据进行分析，以估计群体PK参数。出生体重范围为600至3 620 g（平均1 520 g），胎龄范围为24至42周（平均31周）。使用NONMEM（一种设计用于群体PK分析的计算机程序）分析数据。平均值（.+-.苯巴比妥的清除率CV为0.0047升/小时/千克（±）。19%）和平均值（. ±. CV）分布容积（Vd）为0.96升/kg（±）。16%）。计算的平均血清半衰期为141 h。清除率不受胎龄、性别、窒息或治疗持续时间的影响。Vd不受胎龄或性别的影响，但在窒息的情况下增加了13%（5分钟Apgar评分< 5，p < 0.05）。
Routine clinical pharmacokinetic (PK) data collected from 59 preterm infants who received phenobarbital were analyzed to estimate population PK parameters. Birth weights ranged from 600 to 3,620 g (mean 1,520 g), and gestational ages ranged from 24 to 42 weeks (mean 31 weeks). Data were analyzed using NONMEM, a computer program designed for population PK analysis. The mean (.+-. CV) clearance of phenobarbital was 0.0047 liter/h/kg (.+-. 19%) and the mean (.+-. CV) volume of distribution (Vd) was 0.96 liter/kg (.+-. 16%). The calculated mean serum half-life was 141 h. Clearance was not affected by gestational age, sex, asphyxia, or duration of therapy. Vd was not affected by gestational age or sex but was increased by 13% in the presence of asphyxia (5-min Apgar score < 5, p < 0.05).