Challenges in the use of 1D nanostructures for on-chip biosensing and diagnostics: A review
Challenges in the use of 1D nanostructures for on-chip biosensing and diagnostics: A review
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DOI：
10.1016/j.bios.2010.07.041
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发表时间：
2010-12-15
影响因子：
12.6
通讯作者：
Balasubramanian, Kannan
中科院分区：
文献类型：
--
作者：
Balasubramanian, Kannan
本文综述了利用一维纳米结构（1D-NS）在芯片上检测生物分子。这里讨论的材料包括碳纳米管，金属和半导体纳米线和纳米通道。虽然纳米管和纳米线主要用作电检测器，但纳米通道在分离、预浓缩和DNA映射等应用中是有前途的光学检测框架。对所有三种类型的1D-NS的主要期望在于最终的单分子检测的承诺。此外，双电层在所有三个系统中控制生物传感背后的物理学。该审查开始于由于使用1D纳米结构而产生的优势，然后讨论基本方面，如双层效应和传感方法。然后介绍了三种一维NS。审查的主要重点是深入分析目前在该领域取得的成就，以及在芯片实验室设备和即时诊断等应用中广泛使用这种纳米结构所要克服的主要挑战。(C)2010 Elsevier B. V.保留所有权利。
This review outlines the use of one-dimensional nanostructures (1D-NS) for the detection of biomolecules on a chip. The materials discussed here include carbon nanotubes, metallic and semiconducting nanowires and nanochannels. While nanotubes and naowires have predominantly been used as electrical detectors, nanochannels are promising frameworks for optical detection in applications such as separation, preconcentration and DNA mapping. The primary expectation for all the three types of 1D-NS lies in the promise for ultimate single molecule detection. Furthermore, the electrical double layer governs the physics behind biosensing in all the three systems. The review starts by shedding light on the advantages arising due to the use of 1D nanostructures, followed by a discussion of fundamental aspects such as double layer effects and sensing methodologies. After this, the three kinds of 1D-NS are introduced. The main focus of the review is an in-depth analysis of the current achievements in the field and the major challenges that are to be overcome for the widespread use of such nanostructures in applications such as lab-on-a-chip devices and point-of-care diagnostics. (C) 2010 Elsevier B.V. All rights reserved.