Plasma vascular endothelial growth factor B is elevated in non-alcoholic fatty liver disease patients and associated with blood pressure and renal dysfunction.
Plasma vascular endothelial growth factor B is elevated in non-alcoholic fatty liver disease patients and associated with blood pressure and renal dysfunction.
复制标题
非酒精性脂肪肝患者血浆血管内皮生长因子 B 升高，并与血压和肾功能障碍相关
DOI：
10.17179/excli2020-2647
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发表时间：
2020
期刊：
影响因子：
4.6
通讯作者：
Chen LL
中科院分区：
文献类型：
--
作者：
Ye X;Kong W;Zafar MI;Zeng J;Yang R;Chen LL
血管内皮生长因子B（VEGF-B）是胰岛素抵抗和脂质分布的重要代谢调节因子。我们的目的是确定循环VEGF-B和非酒精性脂肪性肝病（NAFLD）之间的关系，在一般公众。我们共招募了194名普通参与者进行常规身体健康检查;其中，84名参与者根据超声检查结果被确定为NAFLD，110名没有NAFLD。采用稳态模型评价胰岛素抵抗（HOMA-IR）、体重指数（BMI）、糖化血红蛋白（HbA1c）、肝肾功能、血浆VEGF-B水平及代谢综合征指标（血压、空腹血糖、空腹血脂）。NAFLD患者的血浆VEGF-B值显著高于非NAFLD患者（P = 0.022），协方差分析证实了这一结果。单因素分析显示VEGF-B与γ-谷氨酰转肽酶（γ-GT）、HOMA-IR呈正相关（分别为q = 0.242; P = 0.001; q = 0.174; P = 0.019）。多元线性回归分析显示，γ-GT和ALT与VEGF-B独立相关（q = 0.286; P = 0.01; q = 0.237; P = 0.033）。此外，血浆VEGF-B显示出与血压和肾功能不全的强相关性。血浆VEGF-B可能是一个新的与NAFLD相关的临床变量，可作为早期检测高血压和肾功能不全的生物标志物。然而，需要进一步的大队列研究来验证我们的发现。
Vascular endothelial growth factor B (VEGF-B) is a critical metabolic regulator in insulin resistance, and lipid distribution. We intended to ascertain the relationship between circulating VEGF-B and non-alcoholic fatty liver disease (NAFLD) in the general public. We recruited a total of 194 general participants for a routine physical health examination; of these, 84 participants were identified with NAFLD and 110 without NAFLD based on ultrasonographic findings. Homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI), HbA1c, liver function, kidney function, plasma VEGF-B levels and indexes of metabolic syndrome (blood pressure, fasting plasma glucose, fasting lipids) were evaluated. Plasma VEGF-B values were significantly higher in individuals with NAFLD compared to those without NAFLD (P = 0.022), and analysis of covariance confirmed this result. VEGF-B showed a positive correlation with γ-glutamyl transpeptidase (γ-GT) and HOMA-IR in univariate analysis (q = 0.242; P = 0.001; q =0.174; P = 0.019, respectively). Multiple linear regression analysis showed that γ-GT and ALT were independently correlated with VEGF-B even after adjusted for gender and age (q = 0.286; P = 0.01; q =0.237; P = 0.033, respectively). Moreover, plasma VEGF-B showed a powerful correlation with blood pressure and renal dysfunction. Plasma VEGF-B might be a new clinical variable related to NAFLD and could be a proper biomarker for the early detection of hypertension and renal dysfunction. However, further studies with large cohorts' size are warranted to validate our findings.
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DOI：
10.1002/hep.26455
发表时间：
2013-12
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Noureddin M;Lam J;Peterson MR;Middleton M;Hamilton G;Le TA;Bettencourt R;Changchien C;Brenner DA;Sirlin C;Loomba R
通讯作者：
Loomba R
影响因子：
64.8
作者：
Hagberg, Carolina E.;Falkevall, Annelie;Eriksson, Ulf
通讯作者：
Eriksson, Ulf
影响因子：
4
作者：
Chen, Yang;Zhao, Mingyue;Zheng, Yaowu
通讯作者：
Zheng, Yaowu
影响因子：
5.9
作者：
Kitade H;Chen G;Ni Y;Ota T
通讯作者：
Ota T
影响因子：
13.5
作者：
Birkenfeld, Andreas L.;Shulman, Gerald I.
通讯作者：
Shulman, Gerald I.