Peripheral differential leukocyte counts and subsequent mortality from all diseases, cancers, and cardiovascular diseases in Taiwanese.
Peripheral differential leukocyte counts and subsequent mortality from all diseases, cancers, and cardiovascular diseases in Taiwanese.
复制标题
DOI：
10.29828/jfma.200311.0005
复制
发表时间：
2003-11
期刊：
影响因子：
--
通讯作者：
Zei-Shung Huang;K. Chien;Chi-Yu Yang;Chiu-Hwa Wang;Tien-Chun Chang;Chien-Jen Chen
中科院分区：
文献类型：
--
作者：
Zei-Shung Huang;K. Chien;Chi-Yu Yang;Chiu-Hwa Wang;Tien-Chun Chang;Chien-Jen Chen
背景和目的据报道，较高的总白细胞计数可预测男性的全因死亡率，但关于女性白细胞计数与全因死亡率之间的关系以及男女白细胞分类计数与全因死亡率之间的关系的数据有限。本研究旨在分析这些关系在台湾。方法以1995 ~ 1997年间在台大医院接受健康检查的8447名健康人为研究对象。关于死亡率的资料来自一个国家死亡率数据库，该数据库已更新至2001年底。数据采用Student t检验和考克斯回归分析。结果245例死亡病例中，癌症死亡88例，心血管疾病死亡62例。考克斯回归分析显示，研究组的淋巴细胞计数与全因死亡率呈负相关（所有受试者，p < 0.01，风险比= 0.73）。这种负相关主要是由于淋巴细胞计数与癌症死亡率之间的负相关（p < 0.05，风险比= 0.64），特别是肝癌死亡率（p = 0.010，风险比= 0.29）。后者的风险比为0.29，表明在所有受试者中，在平均65.5个月的随访期间，淋巴细胞计数每减少1.0 x 10（9）/L，肝癌死亡风险就会增加3.45倍。男性总白细胞计数与全因死亡率呈正相关（p < 0.05，风险比= 1.10），主要是由于中性粒细胞和单核细胞计数与心血管死亡率呈正相关（均p < 0.05，风险比分别为1.23和1.22）。后者的风险比为1.22，表明在男性中，单核细胞计数每增加0.1 × 10（9）/L，心血管死亡风险增加1.22倍。结论在台湾成年男女中，淋巴细胞计数较低与癌症死亡率相关，尤其是肝癌死亡率。在台湾男性中，较高的中性粒细胞和单核细胞计数与心血管死亡率相关。
BACKGROUND AND PURPOSE A higher total leukocyte count has been reported to predict all-cause mortality in men, but data are limited for this relation in women and for the relation between differential leukocyte counts and all-cause mortality in both men and women. This study was designed to analyze these relationships in Taiwanese. METHODS A total of 8447 subjects were enrolled from participants in a physical check-up program at National Taiwan University Hospital from 1995 to 1997. Information on mortality was obtained from a national mortality databank that was updated to the end of 2001. Data were analyzed by Student's t test and Cox regression analysis. RESULTS Among the 245 deaths, 88 were due to cancer and 62 were due to cardiovascular diseases. Cox regression analysis revealed an inverse association between lymphocyte count and all-cause mortality in the study group as a whole (all subjects, p < 0.01, hazard ratio = 0.73). This inverse association was mainly due to an inverse association between lymphocyte count and cancer mortality (p < 0.05, hazard ratio = 0.64), especially the mortality from hepatoma (p = 0.010, hazard ratio = 0.29). The latter hazard ratio of 0.29 indicates that, in all subjects, every decrease of 1.0 x 10(9)/L in lymphocyte count increased the risk of mortality from hepatoma by 3.45-fold during an average follow-up period of 65.5 months. There was a positive association between total leukocyte count and all-cause mortality in men (p < 0.05, hazard ratio = 1.10), mainly due to both the neutrophil and monocyte counts having positive associations with the cardiovascular mortality (both p < 0.05, hazard ratio = 1.23 and 1.22, respectively). The latter hazard ratio of 1.22 indicates that, in men, every increase of 0.1 x 10(9)/L in monocyte count increased the risk of cardiovascular mortality by 1.22-fold. CONCLUSIONS In Taiwanese adults of both genders, a lower lymphocyte count is associated with cancer mortality, especially mortality from hepatoma. In Taiwanese men, higher neutrophil and monocyte counts are associated with cardiovascular mortality.