Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin
Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin
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DOI：
10.3177/jnsv.65.278
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发表时间：
2019-01-01
影响因子：
1.6
通讯作者：
Sakai, Tohru
中科院分区：
文献类型：
--
作者：
Nakamoto, Akiko;Mitani, Mami;Sakai, Tohru
本文研究了川陈皮素（5，6，7，8，3 '，4'-六甲氧基黄酮）对卵清蛋白（OVA）免疫小鼠免疫应答的影响。用川陈皮素处理增加了OVA特异性IL-4和IL-10的产生。此外，与对照组小鼠相比，接受诺必利的小鼠显示出更高水平的OVA特异性IgE、IgG和IgG 1产生。对胸腺非依赖性抗原2，4，6-三硝基苯基-Ficoll的抗体应答在对照组和川陈皮组中没有差异，表明川陈皮不直接刺激抗体产生。体外研究表明，用诺贝尔碱处理增强了骨髓来源的树突状细胞的抗原呈递能力。在体内和体外的结果表明，诺贝尔调节免疫功能。
We examined the effect of nobiletin (5,6,7,8,3', 4'-hexamethoxyflavone) on immune response in ovalbumin (OVA)-immunized mice. Treatment with nobiletin increased OVA-specific IL-4 and IL-10 production. In addition, mice that received nobiletin showed higher levels of OVA-specific IgE, IgG and IgG1 production than did control mice. The antibody response to the thymus-independent antigen 2,4,6-trinitrophenyl-Ficoll was not different in the control and nobiletin groups, suggesting that nobiletin does not directly stimulate antibody production. An in vitro study showed that treatment with nobiletin enhanced the ability of antigen presentation of bone marrow-derived dendritic cells. The in vivo and in vitro results indicate that nobiletin regulates immune function.