A Healthy Dietary Pattern at Midlife, Combined with a Regulated Energy Intake, Is Related to Increased Odds for Healthy Aging
A Healthy Dietary Pattern at Midlife, Combined with a Regulated Energy Intake, Is Related to Increased Odds for Healthy Aging
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DOI：
10.3945/jn.115.210740
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发表时间：
2015-09-01
影响因子：
4.2
通讯作者：
Kesse-Guyot, Emmanuelle
中科院分区：
文献类型：
--
作者：
Assmann, Karen E.;Lassale, Camille;Kesse-Guyot, Emmanuelle
背景资料：很少有研究调查了整体饮食模式（DP）对健康老龄化（HA）的长期影响，目前的研究结果是不一致的。目的：我们的研究目的是调查经验得出的DP在中年和HA之间的关联后，13年的随访。方法：来自重复24小时饮食记录的基线饮食数据（平均而言，每个参与者10个记录）的子样本的SU.VI.MAX（SUpplementation en Vitamines et Mineraux AntioXydants）研究允许使用37种食物组的主成分分析提取2种DP。2007-2009年，在SU.VI.MAX研究的2796名参与者中评估了HA，基线时（1994-1995年）年龄为45-60岁，最初无糖尿病、心血管疾病和癌症。HA定义为未发生任何重大慢性疾病，身体和认知功能良好，日常生活工具性活动无限制，无抑郁症状，社交生活无健康相关限制，总体自我感知健康良好，无功能限制性疼痛。DP（三分位数）和HA之间的关联进行了评估，通过使用多变量logistic回归，并与能量inade.Results的潜在的相互作用进行了调查：一个“西方”和“健康”的DP被确定。在调整大量潜在混杂因素后，Western DP和HA之间没有显著相关性。此外，在高（即，大于或等于中位数）能量摄入。在低（即，另一方面，健康DP的较高分数与HA的较高几率相关（三分位数3与三分位数1的OR：1.49; 95%CI：1.11，2.00; P趋势= 0.01）。结论：在中年坚持提供微量营养素、纤维和抗氧化剂的健康饮食，同时调节能量摄入可能有助于促进HA。
Background: Few studies have investigated the long-term impact of overall dietary patterns (DPs) on healthy aging (HA), and current findings are inconsistent.Objective: Our study's objective was to investigate the association between empirically derived DPs in midlife and HA after 13 y of follow-up.Methods: Baseline dietary data from repeated 24-h dietary records (on average, 10 records per participant) of a subsample of the SU.VI.MAX (SUpplementation en Vitamines et Mineraux AntioXydants) study allowed extraction of 2 DPs with the use of principal components analysis on 37 food groups. HA was assessed in 2007-2009 among 2796 participants of the SU.VI.MAX study aged 45-60 y at baseline (1994-1995), who were initially free of diabetes, cardiovascular disease, and cancer. HA was defined as not developing any major chronic disease, good physical and cognitive functioning, no limitations in instrumental activities of daily living, no depressive symptoms, no health-related limitations in social life, good overall self-perceived health, and no function-limiting pain. The association between DPs (in tertiles) and HA was evaluated by using multivariable logistic regression, and a potential interaction with energy intake was investigated.Results: A "Western'' and a "healthy'' DP were identified. After adjustment for a large number of potential confounders, there was no significant association between the Western DP and HA. Moreover, the healthy pattern was not associated with HA among subjects with high (i.e., greater than or equal to the median) energy intake. Among subjects with low (i.e., less than the median) energy intake, on the other hand, higher scores on the healthy DP were related to higher odds of HA (OR for tertile 3 vs. tertile 1: 1.49; 95% CI: 1.11, 2.00; P-trend = 0.01).Conclusion: Adherence to a healthy diet in midlife that provides micronutrients, fiber, and antioxidants while regulating energy intake may help to promote HA.