The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)
The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)
复制标题
铝离子对人胰岛淀粉样多肽聚集的影响(11-28)
DOI：
10.1093/abbs/gmx015
复制
发表时间：
2017
影响因子：
3.7
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Su Lanlan;Lu Cheng;Yan Peng;Zhang Nan;Zhou Xingfei;Cai Sheng;Zhang Gongjun;Li Bin;Zhou XF;Li B
Metal ions play a critical role in human islet amyloid polypeptide (hIAPP) aggregation, which is believed to be closely associated with β-cell death in type II diabetes. In this work, the effect of Al3+on the aggregation of hIAPP (11-28) was studied by several different experimental approaches. Atomic force microscopy measurements showed that Al3+could remarkably inhibit hIAPP(11-28) fibrillogenesis, while Zn2+had a slight promotion effect on peptide aggregation, which was also confirmed by Thioflavin T fluorescence observation. Furthermore, X-ray photoelectron spectroscopy measurement indicated that Al ions might form chemical bonds with neighboring atoms and destroy the secondary structures of the protein. Our studies could deepen the understanding of the role of metal ions in the aggregation of amyloid peptides.
