Primary and secondary neural networks of auditory prepulse inhibition: a functional magnetic resonance imaging study of sensorimotor gating of the human acoustic startle response
Primary and secondary neural networks of auditory prepulse inhibition: a functional magnetic resonance imaging study of sensorimotor gating of the human acoustic startle response
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DOI：
10.1111/j.1460-9568.2007.05858.x
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发表时间：
2007-10-01
影响因子：
3.4
通讯作者：
Schall, Ulrich
中科院分区：
文献类型：
--
作者：
Campbell, Linda E.;Hughes, Matthew;Schall, Ulrich
前馈抑制缺陷在一系列神经精神疾病中得到了一致的证明，在评估感觉运动门控时，使用声惊眨眼反射的预脉冲抑制（PPI）。虽然急性失智大鼠可以记录到PPI，但行为学、药理学和心理生理学研究表明，从脑干核延伸到高级皮质区域的复杂神经网络参与了PPI。本研究以16名健康志愿者为研究对象，探讨了声惊眨眼反射中PPI的神经网络及其与肌电图记录PPI的关系。采用稀疏成像设计来模拟在120 ms或480 ms刺激开始前异步或无预脉冲时，血氧水平依赖（BOLD）对声惊吓探针的信号变化。在120毫秒的预脉冲条件下，肌电图证实了感觉运动门控，而在480毫秒的预脉冲条件下，惊吓反应与单独惊吓反应没有差异。BOLD对比的多元回归分析发现，脑桥、丘脑、尾状核、左角回和双侧前扣带的激活与肌电记录的感觉运动门控有关。计划对比证实，与120毫秒脉冲前相比，单独惊吓时脑桥激活增加，而相反对比则证实前额上回激活增加。我们的发现与感觉运动门控的初级桥脑回路相一致，该回路通过丘脑和纹状体与顶叶下皮层、颞叶上皮层、额叶皮层和前额叶皮层相互连接。前额叶、额叶和颞上皮层的PPI过程在功能上与感觉运动门控不同。
Feedforward inhibition deficits have been consistently demonstrated in a range of neuropsychiatric conditions using prepulse inhibition (PPI) of the acoustic startle eye-blink reflex when assessing sensorimotor gating. While PPI can be recorded in acutely decerebrated rats, behavioural, pharmacological and psychophysiological studies suggest the involvement of a complex neural network extending from brainstem nuclei to higher order cortical areas. The current functional magnetic resonance imaging study investigated the neural network underlying PPI and its association with electromyographically (EMG) recorded PPI of the acoustic startle eye-blink reflex in 16 healthy volunteers. A sparse imaging design was employed to model signal changes in blood oxygenation level-dependent (BOLD) responses to acoustic startle probes that were preceded by a prepulse at 120 ms or 480 ms stimulus onset asynchrony or without prepulse. Sensorimotor gating was EMG confirmed for the 120-ms prepulse condition, while startle responses in the 480-ms prepulse condition did not differ from startle alone. Multiple regression analysis of BOLD contrasts identified activation in pons, thalamus, caudate nuclei, left angular gyrus and bilaterally in anterior cingulate, associated with EMG-recorded sensorimotor gating. Planned contrasts confirmed increased pons activation for startle alone vs 120-ms prepulse condition, while increased anterior superior frontal gyrus activation was confirmed for the reverse contrast. Our findings are consistent with a primary pontine circuitry of sensorimotor gating that interconnects with inferior parietal, superior temporal, frontal and prefrontal cortices via thalamus and striatum. PPI processes in the prefrontal, frontal and superior temporal cortex were functionally distinct from sensorimotor gating.