Micromolar concentration of kynurenic acid in rat small intestine
Micromolar concentration of kynurenic acid in rat small intestine
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DOI：
10.1007/s00726-007-0631-z
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发表时间：
2008-08-01
期刊：
影响因子：
3.5
通讯作者：
Turski, W. A.
中科院分区：
文献类型：
--
作者：
Kuc, D.;Zgrajka, W.;Turski, W. A.
犬尿烯酸是谷氨酸和α-7烟碱乙酰胆碱受体的拮抗剂，也是主要在免疫和胃肠道组织中表达的g蛋白偶联受体GPR 35的激动剂。在这项研究中，我们报告，犬尿烯酸是存在于大鼠小肠腔中的微摩尔浓度足以影响GPR 35受体。此外，我们表明犬尿烯酸可以由大肠杆菌产生。我们认为犬尿烯酸可以调节胃肠道功能和完整性。
Kynurenic acid is an antagonist of glutamate and alpha-7 nicotinic acetylcholine receptors and an agonist of the g-protein-coupled receptor GPR35, which is predominantly expressed in immune and gastrointestinal tissues. In this study, we report that kynurenic acid is present in the lumen of rat small intestine in micromolar concentration sufficient to affect the GPR35 receptor. Moreover, we show that kynurenic acid can be produced by Escherichia coli. We suggest that kynurenic acid may modulate gastrointestinal function and integrity.