A combined linkage-physical map of the human genome
A combined linkage-physical map of the human genome
复制标题
DOI：
10.1086/426405
复制
发表时间：
2004-12-01
影响因子：
9.8
通讯作者：
Matise, TC
中科院分区：
文献类型：
--
作者：
Kong, X;Murphy, K;Matise, TC
我们已经从头构建了一个高分辨率的遗传图谱，其中包括最大的一组，据我们所知，多态性标记（N = 14，759），其基因型数据是公开的;它结合了来自人类多态性研究中心（CEPH）和deCODE家系的基因型数据;它结合了单核苷酸多态性;还结合了基于序列的位置信息。我们的图谱上所有标记的位置都得到了基因组序列和基于重组的数据的证实。这种特定的功能组合最大限度地提高了标记的包含，覆盖范围和分辨率，使这张地图唯一适合作为一个全面的资源，用于确定遗传图谱信息（顺序和距离）的任何大型多态性标记。
We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N = 14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers.