Association between serum levels of adiponectin and polychlorinated biphenyls in Korean men and women
Association between serum levels of adiponectin and polychlorinated biphenyls in Korean men and women
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DOI：
10.1007/s12020-014-0231-0
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发表时间：
2015-02-01
期刊：
影响因子：
3.7
通讯作者：
Jee, Sun Ha
中科院分区：
文献类型：
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作者：
Lim, Jung-eun;Jee, Sun Ha
持久性有机污染物（POP）是与代谢综合征和2型糖尿病相关的内分泌干扰化学品。在人类中，人们对它们在肥胖中的潜在作用知之甚少。脂联素增强胰岛素对葡萄糖稳态的影响。肥胖、胰岛素抵抗和2型糖尿病患者脂联素的表达减少。本研究的目的是揭示是否积累的持久性有机污染物，特别是多氯联苯（PCBs），与韩国人的血清脂联素水平。这项横断面研究包括98名韩国人（49名男性和49名女性）。通过Agilent 7890 GC-micro-ECD（气相色谱-微电子捕获检测器）测量标记PCB（PCB 28、52、101、138、153和180）的血清水平。总脂联素水平通过酶联免疫吸附试验进行定量。我们通过使用BMI的中位数（男性24.6 kg/m2;女性23.0 kg/m2）来定义高（千分之一日元中位数）和低（<中位数）体重指数（BMI）组。PCB 28、PCB 138和PCB 153与脂联素水平呈显著负相关（PCB 28的β系数为-0.00741; PCB 138为-0.00438; PCB 153为-0.00406）。当我们按性别划分受试者时，PCB 28和PCB 153与女性的脂联素呈负相关。在高BMI组（中位数为千分之一），PCB 153与脂联素水平呈显著负相关（P < 0.05）。然而，在低BMI组中没有发现这些相关性。总之，我们发现多氯联苯和脂联素之间存在负相关。这项横断面研究可以为持久性有机污染物暴露可能导致2型糖尿病和肥胖的假设提供支持。
Persistent organic pollutants (POPs) are endocrine-disrupting chemicals associated with metabolic syndrome and type 2 diabetes. In humans, little is known about their potential role on obesity. Adiponectin augments the effects of insulin on glucose homeostasis. The expression of adiponectin is reduced in obesity, insulin resistance, and type 2 diabetes. The aim of this study is to reveal whether accumulation of the POPs, especially polychlorinated biphenyls (PCBs), is associated with serum levels of adiponectin in Koreans. This cross-sectional study includes 98 Koreans (49 men and 49 women). Serum levels of marker PCBs (PCB 28, 52, 101, 138, 153, and 180) were measured by Agilent 7890GC-micro-ECD (Gas chromatography-micro-electron capture detector). Total adiponectin levels were quantified by enzyme-linked immunosorbent assay. We defined high (a parts per thousand yenMedian) and low (< Median) body mass index (BMI) groups by using median value of BMI (24.6 kg/m(2) for men; 23.0 kg/m(2) for women). PCB28, PCB138, and PCB153 were significantly negatively associated with adiponectin levels (beta-coefficients = -0.00741 for PCB28; -0.00438 for PCB138; -0.00406 for PCB153). When we divided subjects by sex, PCB28 and PCB153 were inversely associated with adiponectin in women. In the high BMI group (a parts per thousand yenMedian), PCB153 showed the significant negative associations with adiponectin levels (P < 0.05). However, these associations were not seen in the low BMI group. In conclusion, we found negative associations between PCBs and adiponectin. This cross-sectional study could provide support for the hypothesis that POPs exposure might contribute to type 2 diabetes as well as obesity.