Impact of high-sensitivity C-reactive protein on predicting long-term mortality of acute myocardial infarction
Impact of high-sensitivity C-reactive protein on predicting long-term mortality of acute myocardial infarction
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DOI：
10.1016/s0002-9149(03)00106-1
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发表时间：
2003-04-15
影响因子：
2.8
通讯作者：
Hori, M
中科院分区：
文献类型：
--
作者：
Kinjo, K;Sato, H;Hori, M
尽管急性心肌梗死（AMI）后不久测定的C反应蛋白（CRP）浓度与梗死面积相关，但其预后价值仍存在争议。再灌注可加速CRP的降低。因此，CRP浓度，在稳定期的AMI患者治疗主要是再灌注治疗，可能是独立的梗死面积和预测长期死亡率。我们研究了1999年4月至2001年6月期间在大坂急性冠状动脉功能不全研究中登记的1,309例AMI患者。在稳定期（平均AMI发作后25天）测量CRP。患者平均随访522天。90%的患者进行了再灌注治疗。CRP值最高四分位数（大于或等于0.38 mg/dl）的患者年龄较大，糖尿病患病率较高，Killip分级高于较低三个四分位数的患者（
Although the C-reactive protein (CRP) concentration measured shortly after acute myocardial infarction (AMI) is associated with infarct size, its prognostic value is controversial. The reduction of CRP is accelerated by reperfusion. Therefore, the CRP concentration, measured during the stable phase of AMI in patients treated predominantly with reperfusion therapies, may be independent of infarct size and may predict long-term mortality. We studied 1,309 patients with AMI enrolled in the Osaka Acute Coronary Insufficiency Study between April 1999 and June 2001. CRP was measured during the stable phase (mean 25 days after AMI onset). The patients were followed for an average of 522 days. Reperfusion therapies were performed in 90% of the patients. Patients in the highest quartile of CRP values (greater than or equal to0.38 mg/dl) were older, had higher prevalences of diabetes mellitus, and had higher Killip classes than patients in the lower 3 quartiles (