Adherence to Mediterranean diet reduces the risk of metabolic syndrome: A 6-year prospective study
Adherence to Mediterranean diet reduces the risk of metabolic syndrome: A 6-year prospective study
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DOI：
10.1016/j.numecd.2012.02.005
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发表时间：
2013-07-01
影响因子：
3.9
通讯作者：
Lairon, D.
中科院分区：
文献类型：
--
作者：
Kesse-Guyot, E.;Ahluwalia, N.;Lairon, D.
背景和目的：有人提出地中海饮食对 MetS 风险有益，但一般人群的总体前瞻性证据有限。首次在欧洲的一个大型队列中评估了坚持地中海饮食与 MetS 及其成分的 6 年风险之间的前瞻性关联。方法和结果：纳入的受试者是补充维生素和矿物质抗氧化剂 (SU.VI.MAX) 研究的参与者。使用传统地中海饮食评分 (MDS)、更新的地中海评分 (MED) 和根据至少三个 24 小时记录计算的地中海风格饮食模式评分 (MSDPS) 来评估对地中海饮食的依从性。在 3232 名受试者中，评估了地中海饮食评分与 6 年 MetS 风险之间的关联。还估计了地中海评分与 MetS 成分之间的关联。在多变量模型中，随着 MED 评分（P-趋势 = 0.001）和 MDS（P-趋势 = 0.03）的增加，观察到 MetS 的风险较低。 MED 评分和 MDS 最高与最低三分位数的受试者中，MetS 风险的调整后比值比（95% 置信区间）分别为 0.47 (0.32-0.69) 和 0.50 (0.32-0.77)。 MED 评分与腰围、收缩压和甘油三酯呈负相关，与 HDL-胆固醇直接相关。 MDS 与腰围和甘油三酯呈负相关，MSDPS 与 HDL 胆固醇呈正相关。结论：所有地中海饮食评分均与 MetS 组成部分或 MetS 发生率呈潜在有益的方向相关。我们的研究结果支持应鼓励个人遵循地中海饮食模式以降低代谢综合征风险。试验注册：clinicaltrials.gov 标识符：NCT00272428。 (C) 2012 Elsevier B.V. 保留所有权利。
Background and aims: Benefits of Mediterranean diet on MetS risk have been suggested, but overall prospective evidence in the general population is limited. For the first time, the prospective association of adherence to Mediterranean diet with the 6-y risk of MetS and its components was evaluated in a large cohort in Europe.Methods and results: Subjects included were participants from the Supplementation en Vitamines et Mineraux AntioXydants (SU.VI.MAX) study. Adherence to Mediterranean diet was assessed using traditional Mediterranean diet score (MDS), an updated Mediterranean score (MED) and Mediterranean style-dietary pattern score (MSDPS) calculated from at least three 24-h records. In 3232 subjects, the association between Mediterranean diet scores and 6-y risk of MetS was evaluated. The association between Mediterranean scores and MetS components was also estimated. A lower risk of MetS was observed with increasing MED score (P-trend = 0.001) and MDS (P-trend = 0.03) in multivariate models. The adjusted odds ratios (95% Confidence Interval) for MetS risk were 0.47 (0.32-0.69) and 0.50 (0.32-0.77) in subjects in the highest versus lowest tertile of MED score and MDS, respectively. The MED score was inversely associated with waist circumference, systolic blood pressure and triglycerides, and directly associated with HDL-cholesterol. The MDS was negatively associated with waist circumference and triglycerides, and MSDPS was positively associated with HDL-cholesterol.Conclusions: All Mediterranean diet scores were associated in a potentially beneficial direction with components of MetS or MetS incidence. Our findings support that individuals should be encouraged to follow a Mediterranean dietary pattern for reduction of MetS risk. Trial Registration: clinicaltrials.gov Identifier: NCT00272428. (C) 2012 Elsevier B.V. All rights reserved.