Cardiovascular effects of antidepressant drugs
Cardiovascular effects of antidepressant drugs
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抗抑郁药物的心血管作用
DOI：
10.3109/08039489309104124
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发表时间：
1993
影响因子：
1.8
通讯作者：
X. Preud’homme
中科院分区：
文献类型：
--
作者：
A. Glassman;S. Roose;S. Rivelli;X. Preud’homme
本文综述了三环类抗抑郁药对心血管作用的数据。尽管三环类药物过量时具有心脏毒性，但在治疗剂量下，除体位性低血压外，三环类药物对既往无心脏病的抑郁患者表现出相对良性的心血管效应。它们已被证明可延迟传导，表现为标准ECG上PR、QRS和QT间期延长。患有传导疾病，特别是束分支传导阻滞的抑郁患者，在接受治疗血浆水平的TCA治疗时，发生症状性房室传导阻滞的风险高于无传导疾病的患者。三环类抗抑郁药已被发现可减少室性心律失常，这是1A型抗抑郁药化合物共有的特性。最近，各种1型抗心律失常药已被证明可增加MI后患者的死亡率。这可能对TCA治疗心肌梗死后抑郁患者的影响需要进一步研究。最新的N…
This article reviews data on the cardiovascular effects of tricyclic antidepressants. While cardiotoxic in overdose, at therapeutic doses tricyclics exhibit relatively benign cardiovascular effects in depressed patients without preexisting cardiac disease, with the exception of orthostatic hypotension. They have been shown to delay conduction, manifested by prolonged PR, QRS and QT intervals on the standard ECG. Depressed patients with conduction disease, particularly bundle branch block, when treated with TCAs at therapeutic plasma levels, are at a higher risk of developing symptomatic A-V block than patients free of conduction disorders. Tricyclic antidepressants have been found to reduce ventricular arrhythmias, a property shared with type 1A antiarrhythmic compounds. Recently, a variety of type 1 antiarrhythmics has been shown to increase mortality in post-MI patients. The implications this may have for the TCA treatment of post-myocardial infarction depressed patients needs further study. The newer n...
心律失常抑制试验对抗心律失常药物治疗的影响。
DOI：
10.1016/0002-9149(90)91410-8
发表时间：
1990
期刊：
The American journal of cardiology
影响因子：
--
作者：
BiggerJr,JT
通讯作者：
BiggerJr,JT
恩卡尼、氟卡尼、丙咪嗪和莫雷西嗪对急性心肌梗死后一年内室性心律失常的影响：CAPS。
DOI：
10.1016/0002-9149(88)90754-0
发表时间：
1988
期刊：
The American journal of cardiology
影响因子：
--
作者：
CardiacArrhythmiaPilotStudy(CAPS)Investigators
通讯作者：
CardiacArrhythmiaPilotStudy(CAPS)Investigators