Decrease in haemoglobin oxygenation during absence seizures in adult humans
Decrease in haemoglobin oxygenation during absence seizures in adult humans
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DOI：
10.1016/j.neulet.2003.10.001
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发表时间：
2004-01-09
影响因子：
2.5
通讯作者：
Meierkord, H
中科院分区：
文献类型：
--
作者：
Buchheim, K;Obrig, H;Meierkord, H
近红外光谱（NIRS）是一种非侵入性的方法，可以评估人类激活诱导的皮质氧合变化。已经证明，在功能刺激激活的区域，氧合血红蛋白的增加和脱氧血红蛋白的减少是可以预期的。同样，逆氧合模式已被证明与皮层失活有关。当前研究的目的是确定在失神发作期间发生的氧变化。我们对3例典型失神性癫痫的成人患者同时进行了心电图和视频脑电图遥测。MRS探头放置在F1/F2导联下方的额叶皮层上。在研究的所有失神性癫痫发作期间，注意到大脑hb -氧合的明显变化，而间隔时间没有变化。我们观察到在失神发作期间[脱氧-血红蛋白]可重复减少，[脱氧-血红蛋白]增加，表明皮质活动减少。氧合变化在脑电图定义的缺失发作后几秒钟开始，并比临床定义的事件持续20-30秒。2003爱思唯尔爱尔兰有限公司版权所有。
Near-infrared spectroscopy (NIRS) is a noninvasive method that allows the assessment of activation-induced cortical oxygenation changes in humans. It has been demonstrated that an increase in oxygenated and a decrease in deoxygenated haemoglobin can be expected over an area activated by functional stimulation. Likewise, an inverse oxygenation pattern has been shown to be associated with cortical deactivation. The aim of the current study was to determine the oxygenation changes that occur during absence seizures. We performed ictal MRS simultaneously with video-EEG telemetry in three adult patients with typical absence seizures. MRS probes were placed over the frontal cortex below the F1/F2 leads. During all absence seizures studied, pronounced changes in cerebral Hb-oxygenation were noted and there were no changes in the interval. We observed a reproducible decrease in [oxy-Hb] and an increase in [deoxy-Hb] during absence seizures indicating a reduction of cortical activity. Oxygenation changes started several seconds after the EEG-defined absence onset and outlasted the clinically defined event by 20-30 s. (C) 2003 Elsevier Ireland Ltd. All rights reserved.