Regulation of adaptive immunity by the NLRP3 inflammasome
Regulation of adaptive immunity by the NLRP3 inflammasome
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DOI：
10.1016/j.intimp.2010.11.025
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发表时间：
2011-05-01
影响因子：
5.6
通讯作者：
Meng, Guangxun
中科院分区：
文献类型：
--
作者：
Chen, Mingkuan;Wang, Hongbin;Meng, Guangxun
先天免疫系统可以诱导和调节获得性免疫的发生。NLRP 3炎性体是一种多蛋白复合物，其控制半胱天冬酶-1活化步骤，该步骤是白细胞介素（IL）-1 β和IL-18成熟的先决条件。最近的研究表明，NLRP 3炎性小体不仅是病原和危险信号的天然应答者，而且可以影响适应性免疫应答。本文就NLRP 3炎性体在适应性免疫中的作用作一综述。(C)2010 Elsevier B. V.保留所有权利。
It is well known that the innate immune system can induce and regulate the development of adaptive immunity. The NLRP3 inflammasome is a multiprotein complex that controls the caspase-1 activation step that is a prerequisite for the maturation of interleukin (IL)-1 beta and IL-18. Recent findings showed that the NLRP3 inflammasome not only is an innate responder to pathogenic and danger signals, but also can affect the adaptive immune response. Here we review the role of NLRP3 inflammasome in regulating adaptive immunity. (C) 2010 Elsevier B.V. All rights reserved.