A comparison of the cerebral protective effects of etomidate, thiopental, and isoflurane in a model of forebrain ischemia in the rat.
A comparison of the cerebral protective effects of etomidate, thiopental, and isoflurane in a model of forebrain ischemia in the rat.
复制标题
比较依托咪酯、硫喷妥钠和异氟烷在大鼠前脑缺血模型中的脑保护作用。
作者：
T. Sano;P. Patel;John C. Drummond;D. J. Cole
我们评估了依托咪酯、硫喷妥钠和异氟醚对大鼠缺血性神经元损伤的影响。对照组动物接受1.2%异氟烷。依托咪酯组和硫喷妥钠组的动物接受依托咪酯或硫喷妥钠的输注，直到达到脑电图（EEG）爆发抑制。在第四组中，异氟烷浓度增加至3%（足以产生EEG爆发抑制）。前脑缺血诱导双侧颈动脉闭塞，同时低血压10分钟。缺血后三天，两个盲观察者评价苏木精和伊红染色的冠状面脑切片神经元损伤。依托咪酯组海马腹侧CA1区损伤较对照组轻。硫喷妥钠组的内嗅皮质损伤比对照组少。用1.2%异氟烷和3%异氟烷麻醉的动物的组织学结果没有差异。虽然这些数据表明，依托咪酯和硫喷妥钠可能会减少某些结构的缺血性损伤，所观察到的保护作用的幅度很小。
We evaluated the effect of etomidate, thiopental, and isoflurane on ischemic neuronal injury in rats. Control group animals received 1.2% isoflurane. The animals in the etomidate and thiopental groups received an infusion of either etomidate or thiopental until electroencephalographic (EEG) burst-suppression was attained. In the fourth group, the isoflurane concentration was increased to 3% (sufficient to produce EEG burst-suppression). Forebrain ischemia was induced by bilateral carotid artery occlusion with simultaneous hypotension for 10 min. Three days after ischemia, two blinded observers evaluated neuronal injury in coronal brain sections stained with hematoxylin and eosin. Injury to the ventral CA1 of the hippocampus was less in the etomidate group than in the control group. Injury to the entorhinal cortex was less in the thiopental group than in the control group. Histopathologic outcome in animals anesthetized with 1.2% isoflurane and 3% isoflurane was not different. Although these data indicate that etomidate and thiopental might reduce ischemic injury in some structures, the magnitude of the protective effects observed was small.
影响因子：
8.3
作者：
BUSTO, R;GLOBUS, MY;GINSBERG, MD
通讯作者：
GINSBERG, MD