Sexually transmitted infections and prostatic inflammation/cell damage as measured by serum prostate specific antigen concentration
Sexually transmitted infections and prostatic inflammation/cell damage as measured by serum prostate specific antigen concentration
复制标题
DOI：
10.1016/s0022-5347(05)00892-x
复制
发表时间：
2006-05-01
影响因子：
6.6
通讯作者：
Platz, EA
中科院分区：
文献类型：
--
作者：
Sutcliffe, S;Zenilman, JM;Platz, EA
目的：虽然推测性传播感染引起的炎症和细胞损伤会导致前列腺疾病的后期发展，但很少有临床研究来调查性传播媒介感染前列腺并诱导炎症免疫反应的程度。我们通过测量有记录的性传播感染男性的血清 PSA（前列腺炎症和细胞损伤的可能标志物）来间接研究这个问题。 材料和方法：在巴尔的摩市性传播感染诊所的 2 项前瞻性研究中，对实验室确诊的渗出性传播感染（包括淋病、衣原体和滴虫病）的年轻男性和未诊断出性传播感染的年轻男性的存档血清标本进行了鉴定，即性传播感染传播和获得性研究中的 84 名患者。粘膜免疫研究中的 61。对至少 1 次渗出性 STI 诊断的男性在 STI 诊断之前、期间和之后就诊的血清样本以及未诊断出 STI 的男性所有就诊的血清样本进行了总 PSA 浓度检测。结果：综合研究后，性传播感染患者的 PSA 比未诊断出性传播感染的患者更有可能增加 40% 或更高（32% vs 2%，p < 0.01）。结论：这些研究结果表明，性传播感染可能会导致前列腺炎症以及部分受感染男性的细胞损伤。需要进一步的研究来重复研究结果并确定与 PSA 大幅增加相关的宿主和感染特征。
Purpose: Although inflammation and cell damage due to STIs are hypothesized to contribute to the later development of prostate disease, few clinical studies have been done to investigate the extent to which sexually transmitted agents infect and induce an inflammatory immune response in the prostate. We indirectly investigated this question by measuring serum PSA, a possible marker of prostatic inflammation and cell damage, in men with documented STIs.Materials and Methods: Archived serum specimens from young men with laboratory confirmed exudative STIs, including gonorrhea, chlamydia and trichomonosis, and young men with no STI diagnoses were identified in 2 prospective studies of patients at Baltimore City STI clinics, that is 84 in the STI Transmission and Acquisition Study, and 61 in the Mucosal Immunity Study. Serum specimens from visits before, during and after STI diagnoses in men with at least 1 exudative STI diagnosis and from all visits in men with no STI diagnoses were tested for total PSA concentration.Results: After combining the studies patients with STIs were more likely to have a 40% or greater increase in PSA than patients with no STI diagnoses (32% vs 2%, p < 0.01).Conclusions: These findings suggest that STIs may contribute to prostatic inflammation and cell damage in a subset of infected men. Further studies are warranted to replicate study findings and determine host and infection characteristics associated with large PSA increases.