ROLE OF HOST CELLULAR-RESPONSE IN DIFFERENTIAL SUSCEPTIBILITY OF NONIMMUNIZED BALB/C MICE TO PLASMODIUM-BERGHEI AND PLASMODIUM-YOELII SPOROZOITES
ROLE OF HOST CELLULAR-RESPONSE IN DIFFERENTIAL SUSCEPTIBILITY OF NONIMMUNIZED BALB/C MICE TO PLASMODIUM-BERGHEI AND PLASMODIUM-YOELII SPOROZOITES
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DOI：
10.1128/iai.59.8.2529-2534.1991
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发表时间：
1991-08-01
影响因子：
3.1
通讯作者：
VANDERBERG, JP
中科院分区：
文献类型：
--
作者：
KHAN, ZM;VANDERBERG, JP
我们发现 BALB/c 小鼠对约氏疟原虫的敏感度比伯氏疟原虫子孢子高 2,000 倍，这是通过这些子孢子在免疫学幼稚小鼠的肝脏中分化为显微镜可检测的肝裂殖体的能力来衡量的。决定小鼠对伯氏疟原虫子孢子相对不敏感的因素之一是小鼠注射子孢子后产生的先天细胞炎症反应。注射子孢子后不久，针对伯氏疟原虫的细胞炎症反应就会启动； 24小时后，肝脏内出现了显着的组织病理学变化。针对约氏疟原虫的细胞炎症反应要少得多；直到注射子孢子后约 44 小时肝裂殖体开始破裂后，才观察到肝脏内显着的组织病理学变化。针对两种不同的、密切相关的子孢子物种的细胞炎症反应的这些差异引起了人们的极大兴趣。数据强烈表明 BALB/c-P。 berghei子孢子系统是子孢子免疫研究中相对较差的生物学模型。
We found BALB/c mice to be on the order of 2,000 times more susceptible to Plasmodium yoelii than Plasmodium berghei sporozoites, as measured by the ability of these sporozoites to differentiate into microscopically detectable hepatic schizonts in the livers of immunologically naive mice. One of the factors that determine the relative insusceptibility of mice to P. berghei sporozoites is the innate cellular inflammatory response that the mice mount after injection with sporozoites. The cellular inflammatory response against P. berghei is initiated soon after sporozoite injection; by 24 h, substantial histopathological changes have developed within the liver. There is considerably less of a cellular inflammatory response against P. yoelii; significant histopathological changes within the liver are not observed until well after hepatic schizonts have begun to rupture at around 44 h postinjection of sporozoites. These differences in the cellular inflammatory response against two different, closely related species of sporozoites are of considerable interest. The data strongly suggest that the BALB/c-P. berghei sporozoite system is a relatively poor biological model for sporozoite immunization studies.