Total synthesis of (-)-physovenine from (-)-3a-hydroxyfuroindoline
Total synthesis of (-)-physovenine from (-)-3a-hydroxyfuroindoline
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DOI:
10.1016/j.tetlet.2005.01.016
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发表时间:
2005-02-28
影响因子:
1.8
通讯作者:
Omura, S
中科院分区:
文献类型:
--
作者:
Sunazuka, T;Yoshida, K;Omura, S
Total synthesis of calabar bean alkaloid (-)-physovenine (-)-3 has been achieved in a concise manner starting from optically active (-)-3a-hydroxyfuroindoline (-)-2, synthesized via modified Sharpless epoxidation of tryptophol 1. Our strategy involved a stereospecific radical substitution reaction and regioselective oxidation at the C5 position. (C) 2005 Elsevier Ltd. All rights reserved.