Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection.
Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection.
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DOI：
10.1016/j.ijpharm.2015.10.001
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发表时间：
2015-12
影响因子：
5.8
通讯作者：
A. Suganami;Y. Iwadate;S. Shibata;Masamichi Yamashita;Tsutomu Tanaka;Natsuki Shinozaki;I. Aoki;N. Saeki;H. Shirasawa;Y. Okamoto;Y. Tamura
中科院分区：
文献类型：
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作者：
A. Suganami;Y. Iwadate;S. Shibata;Masamichi Yamashita;Tsutomu Tanaka;Natsuki Shinozaki;I. Aoki;N. Saeki;H. Shirasawa;Y. Okamoto;Y. Tamura
一些肿瘤特异性近红外（NIR）荧光染料如吲哚菁绿（ICG）、IDRye800CW和5-氨基乙酰丙酸已在临床上用于检测肿瘤边缘或微癌病变。在这项研究中，我们评估了脂质体配制的磷脂缀合 ICG（由 LP-iDOPE 表示）作为临床可转化的脑肿瘤近红外成像纳米颗粒的理化特性。我们还证实了其脑肿瘤特异性生物分布及其作为脑肿瘤手术术中近红外成像纳米颗粒的特性。 LP-iDOPE的这些特性可能使神经外科医生能够实现更准确的识别和更完整的脑肿瘤切除。
Some tumor-specific near-infrared (NIR) fluorescent dyes such as indocyanine green (ICG), IDRye800CW, and 5-aminolevulinic acid have been used clinically for detecting tumor margins or micro-cancer lesions. In this study, we evaluated the physicochemical properties of liposomally formulated phospholipid-conjugated ICG, denoted by LP-iDOPE, as a clinically translatable NIR imaging nanoparticle for brain tumors. We also confirmed its brain-tumor-specific biodistribution and its characteristics as the intra-operative NIR imaging nanoparticles for brain tumor surgery. These properties of LP-iDOPE may enable neurosurgeons to achieve more accurate identification and more complete resection of brain tumor.