Interrelationships between dietary restriction, the IGF-I axis, and expression of vascular endothelial growth factor by prostate adenocarcinoma in rats
Interrelationships between dietary restriction, the IGF-I axis, and expression of vascular endothelial growth factor by prostate adenocarcinoma in rats
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DOI：
10.1002/mc.20403
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发表时间：
2008-06-01
影响因子：
4.6
通讯作者：
Clinton, Steven K.
中科院分区：
文献类型：
--
作者：
Powolny, Anna A.;Wang, Shihua;Clinton, Steven K.
人类研究表明，过多的能量摄入和肥胖可能会影响前列腺癌的进展。啮齿动物实验表明，饮食限制会减弱肿瘤生长，同时降低血管密度。本研究探讨了饮食限制引起的胰岛素样生长因子 I (IGF-I) 轴的变化及其与前列腺癌中血管内皮生长因子 (VEGF) 表达的关系。断奶雄性哥本哈根大鼠被随机分为对照组或 40% 饮食限制组 (n=5)。 8周后，将大鼠AT6.3前列腺腺癌细胞植入大鼠体内。两周后，处死动物并收集血清、正常前列腺、肝脏和前列腺肿瘤样本进行分析。饮食限制使 IGF-I 的血清浓度降低了 35%（P
Human studies suggest that excessive energy intake and obesity may influence prostate cancer progression. Rodent experiments demonstrate that diet restriction attenuates tumor growth in parallel with reduced vascular density. The present study examines changes in the insulin-like growth factor I (IGF-I) axis caused by dietary restriction and their association with the expression of vascular endothelial growth factor (VEGF) in prostate cancer. Weanling male Copenhagen rats were randomized into control or 40% dietary restricted groups (n=5). After 8 wk, rats were implanted with rat AT6.3 prostate adenocarcinoma cells. Two weeks later, the animals were sacrificed and serum, normal prostate, liver, and prostate tumor samples were collected for analyses. Dietary restriction reduced serum concentrations of IGF-I by 35% (P