Levels of the oxytocin-associated and vasopressin-associated neurophysins in plasma and their responses in essential hypertension.
Levels of the oxytocin-associated and vasopressin-associated neurophysins in plasma and their responses in essential hypertension.
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血浆中催产素相关和加压素相关神经素的水平及其在原发性高血压中的反应。
DOI：
10.1111/j.1365-2265.1984.tb00085.x
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发表时间：
1984
影响因子：
3.2
通讯作者：
Robinson,AG
中科院分区：
文献类型：
--
作者：
Amico,JA;Corder,CN;McDonaldJr,RH;Robinson,AG
对一组89名原发性高血压患者进行了多项测量，包括被认为是人类催产素神经后叶素（OT-Np）和人类加压素神经后叶素（VP-Np）的神经后叶素。神经垂体素是视上核和室旁核细胞内合成的蛋白质，与它们各自的激素催产素和加压素一起作为共同前体分子的一部分，因此可以反映它们相关激素在血浆中的同时存在。在仰卧位（r= 0.248）或直立位（r= 0.255）时，OT-Np水平与血浆中的肾素活性（PRA）之间存在较差但具有统计学显著性的相关性。OT-Np水平平均为1.75 ng/ml，与肌酐（r=-0.252）、仰卧位血压（r=-0.450）、血浆容量（r=-0.327）和24小时尿钠（r=-0.313）呈负相关。输注生理盐水可抑制Ot-Np水平。在容量扩张状态下，OT‐Np水平较低，与输注后24小时尿液中的钠排泄量呈正相关（r= 0·426），与输注生理盐水后记录的仰卧位收缩压（r=-0·379）和仰卧位舒张压（r=-0·455）呈负相关。雌激素是一种刺激OT-Np分泌的物质，但不能解释研究中观察到的OT-Np升高，因为OT-Np升高的患者亚组（E2= 36 pg/ml）的雌二醇（E2）平均水平与OT-Np值较低的受试者（E2= 45 pg/ml）的水平没有差异。VP-Np水平平均为0.85 ng/ml，与PRA（r= 0.353）和24小时尿多巴胺排泄量（r= 0.44）呈正相关，与年龄（r=-0.263）、血压和24小时尿钠排泄量（r=-0.226）呈负相关。直立姿势导致VP-Np升高。因此，OT‐Np和VP‐Np的水平对某些生理刺激有反应，并且在原发性高血压受试者亚组中OT‐Np的水平升高。
A group of 89 individuals with essential hypertension was evaluated with several measurements including the neurophysin believed to be the human oxytocin neurophysin (OT‐Np), and the human vasopressin neurophysin (VP‐Np). The neurophysins are proteins synthesized within cells of the supraoptic and paraventricular nuclei in conjunction with their respective hormones oxytocin and vasopressin as part of a common precursor molecule and so may reflect the simultaneous presence in plasma of their associated hormones. A poor but statistically significant correlation was noted between levels of OT‐Np and renin activity in plasma (PRA) either supine (r= 0·248) or erect (r= 0·255). Levels of OT‐Np averaged 1·75 ng/ml and were inversely correlated with creatinine (r= ‐ 0·252), supine blood pressure (r= ‐ 0·450), plasma volume (r= ‐ 0·327), and 24‐hour urine sodium (r= ‐ 0·313). Levels of Ot‐Np could be suppressed by infusion of physiologic saline. Levels of OT‐Np were lower in the volume expanded state and were positively correlated with the quantity of sodium excreted into a 24‐hour urine collected after the infusion (r= 0·426) and inversely correlated with the supine systolic (r= ‐ 0·379) and supine diastolic (r= ‐ 0·455) blood pressures recorded after the infusion of saline. Oestrogen, a stimulus to the secretion of OT‐Np, did not account for the elevation of OT‐Np observed in the study, since mean levels of oestradiol (E2) in a subset of the patients with elevated OT‐Np (E2= 36 pg/ml) were not different from levels in subjects with lower values of OT‐Np (E2= 45 pg/ml). Levels of VP‐Np averaged 0·85 ng/ml and correlated positively with PRA (r= 0·353) and 24‐hour urine excretion of dopamine (r= 0·44), and inversely with age (r= ‐ 0·263), blood pressure, and 24‐hour urine excretion of sodium (r= ‐ 0·226). Erect posture caused an elevation of VP‐Np. Therefore, levels of OT‐Np and VP‐Np respond to certain physiological stimuli and levels of OT‐Np are elevated in a subgroup of subjects with essential hypertension.