The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma
The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma
复制标题
DOI：
10.1097/01.pas.0000173646.99337.b1
复制
发表时间：
2005-09-01
影响因子：
5.6
通讯作者：
Young, RH
中科院分区：
文献类型：
--
作者：
Epstein, JI;Allsbrook, WC;Young, RH
1966年，唐纳德·F·格里森创建了一种独特的前列腺癌分级系统，该系统完全基于前列腺癌的结构模式。这个系统的另一个创新方面是，不是将最差的级别指定为癌症的级别，而是将级别定义为两种最常见的级别模式的总和，并报告为格里森评分。对这一系统的原始描述，基于对来自明尼阿波利斯退伍军人管理医院的270名患者的研究，见表1。最初，格里森打算将癌症分为四种模式，但观察到一小群独特的肿瘤(透明细胞)，并将它们归入单独的第五类(模式4)。14在今天的实践中，最初的格里森制度的某些方面将得到不同的解释。被描述为格里森原始图案2和3的组成部分的筛状图案今天通常被认为是更高级别的。格里森最初的模式3中列出的单个细胞目前也将被赋予更高的等级。模式4已经大大超出了Gleason最初描述的具有类似肾细胞癌的透明细胞质的肿瘤(表1)。
Donald F. Gleason in 1966 created a unique grading system for prostatic carcinoma based solely on the architectural pattern of the tumor. 3, 14, 22 Another innovative aspect of this system was, rather than assigning the worst grade as the grade of the carcinoma, the grade was defined as the sum of the two most common grade patterns and reported as the Gleason score. The original description of this system, based on a study of 270 patients from the Minneapolis Veterans Administration Hospital, is seen in Table 1.Initially, Gleason intended to classify carcinomas into four patterns, but a small group of distinctive tumors (clear cell) was observed and they were placed in a separate fifth category (pattern 4). 14 Certain aspects of the original Gleason system would be interpreted differently in today’s practice. The cribriform pattern described as a component of Gleason’s original patterns 2 and 3 would today typically be considered higher grade. Individual cells listed under Gleason’s original pattern 3 would also be currently assigned a higher grade. Pattern 4 has become significantly expanded beyond Gleason’s original description of tumors with clear cytoplasm that resembled renal cell carcinoma (Table 1).