Anatomy of bipolar disorder and schizophrenia: A meta-analysis
Anatomy of bipolar disorder and schizophrenia: A meta-analysis
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DOI：
10.1016/j.schres.2009.12.022
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发表时间：
2010-03-01
影响因子：
4.5
通讯作者：
Bullmore, Edward T.
中科院分区：
文献类型：
--
作者：
Ellison-Wright, Ian;Bullmore, Edward T.
背景资料：最近的遗传学研究结果表明，精神分裂症和双相情感障碍这两种主要的、典型的不同形式的精神病可能有共同的致病因素。然而，目前尚不清楚他们在多大程度上也可能具有类似的大脑异常特征。我们使用元分析技术来生成和比较地图的大脑结构异常的大样本的患者都已Studied using magnetic resonance imaging.Method：进行了系统的搜索为基础的体素形态学研究，检查灰质的精神分裂症或双相情感障碍患者。灰质差异的坐标的解剖学分布进行了荟萃分析，使用解剖学Likestimation.Results：42精神分裂症的研究，包括2058例精神分裂症患者和2131比较科目进行了比较，14双相研究，包括366例双相情感障碍和497比较科目。在精神分裂症患者中，额叶、颞叶、扣带回和岛叶皮质以及丘脑中存在广泛的灰质缺陷，基底神经节中的灰质增加。在双相情感障碍患者中，前扣带回和双侧大脑中回灰质减少。这些基本上重叠的灰质减少在精神分裂症的领域，除了前扣带回的灰质减少是特定于bipolar disorder.Implications：在双相情感障碍的研究中有一致的区域灰质减少边缘区（前扣带回和前扣带回）牵连在情绪处理。精神分裂症研究中的灰质减少更为广泛，涉及边缘系统和新皮层结构，以及双相情感障碍中受影响的边缘系统军团。(C)2009爱思唯尔有限公司版权所有。
Background: Recent genetic results have indicated that the two major, classically distinct forms of psychosis - schizophrenia and bipolar disorder - may share causative factors in common. However it is not clear to what extent they may also have similar profiles of brain abnormality. We used meta-analytic techniques to generate and compare Maps Of brain Structural abnormality in the large samples of patients with both disorders that have been Studied using magnetic resonance imaging.Method: A systematic search was conducted for voxel-based morphometry studies examining gray matter in patients with schizophrenia or bipolar disorder. The anatomical distribution of the co-ordinates of gray matter differences was meta-analysed using Anatomical Likelihood Estimation.Results: Forty-two schizophrenia studies including 2058 patients with schizophrenia and 2131 comparison subjects were compared with fourteen bipolar Studies including 366 patients with bipolar disorder and 497 comparison Subjects. In schizophrenia, there were extensive gray matter deficits in frontal, temporal, cingulate and insular cortex and thalamus, and increased gray matter in the basal ganglia. In bipolar disorder, gray matter reductions were present in the anterior cingulate and bilateral insula. These substantially overlapped with areas of gray matter reduction in schizophrenia, except for a region of anterior cingulate where gray matter reduction was specific to bipolar disorder.Implications: In bipolar disorder studies there were consistent regional gray matter reductions in paralimbic regions (anterior cingulate and insula) implicated in emotional processing. Gray matter reductions in schizophrenia studies were more extensive and involved limbic and neocortical structures as well as the paralimbic legions affected in bipolar disorder. (C) 2009 Elsevier B.V. All rights reserved.