Induction and maintenance of epileptiform activity in the rabbit olfactory bulb depends on centrifugal input.
Induction and maintenance of epileptiform activity in the rabbit olfactory bulb depends on centrifugal input.
复制标题
兔子嗅球癫痫样活动的诱导和维持取决于离心输入。
DOI：
10.1007/bf00255247
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发表时间：
1987
影响因子：
2
通讯作者：
Skinner,JE
中科院分区：
文献类型：
--
作者：
Gray,CM;Freeman,WJ;Skinner,JE
使用低温封锁技术唤醒兔子，使嗅球与大脑其他部分完全且可逆地隔离。在嗅脚冷却期间，20 次中有 3 次梨状皮层自发发生癫痫样活动，但球部从未发生癫痫样活动。去除冷冻阻断后，在癫痫发作状态下，球和梨状皮层同时出现癫痫样放电。在控制状态下，在没有冷却花梗的情况下，通过对球茎或侧嗅束的强烈电刺激可以在球茎和皮层中诱发癫痫样活动。然而，在冷冻阻断期间，对球部的强烈刺激未能引起癫痫样放电。结果表明，嗅球癫痫样活动的诱导和维持依赖于更中枢的嗅觉结构。
A technique of cryogenic blockade was used in waking rabbits to produce complete and reversible isolation of the olfactory bulb from the rest of the brain. During cooling of the olfactory peduncle epileptiform activity occurred spontaneously in the pyriform cortex in 3 out of 20 sessions, but never in the bulb. Following removal of the cryoblockade, during the seizure state, epileptiform discharges appeared simultaneously in the bulb and pyriform cortex. In the control state, without cooling of the peduncle, epileptiform activity could be evoked in the bulb and cortex by intense electrical stimulation of either the bulb or the lateral olfactory tract. During the cryoblockade, however, intense stimulation of the bulb failed to evoke seizure-like discharges. The results demonstrate a dependency on more central olfactory structures for the induction and maintenance of epileptiform activity in the olfactory bulb.