Impaired sweating function in adult atopic dermatitis: results of the quantitative sudomotor axon reflex test
Impaired sweating function in adult atopic dermatitis: results of the quantitative sudomotor axon reflex test
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DOI：
10.1046/j.1365-2133.2002.04765.x
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发表时间：
2002-10-01
影响因子：
10.3
通讯作者：
Katayama, I
中科院分区：
文献类型：
--
作者：
Eishi, K;Lee, JB;Katayama, I
研究背景：特应性皮炎（atopic dermatitis，AD）患者出汗功能障碍是导致屏障功能障碍的原因之一。目的：定量研究AD患者的出汗功能。方法：采用电离子导入法（acetylcholine ionophoresis，AC）刺激成年AD患者的出汗轴突反射，定量研究AD患者皮损和非皮损皮肤的出汗反应。在18例AD成人患者和40例非特应性对照者中测量前臂掌侧的出汗量; 5例干燥综合征患者也作为疾病对照者进行了研究。我们还评估了4例AD患者外用皮质类固醇治疗后的出汗功能。结果与正常对照组相比，AD患者的潜伏期明显延长，轴反射介导的间接出汗量明显减少。AD皮损皮肤的潜伏期和AXR汗液量分别比非皮损皮肤显著延长和减少。与此相反，与非特应性对照相比，由乙酰胆碱直接刺激诱导的病变或非病变AD皮肤的出汗量仅略有减少。潜伏期时间和汗水体积的病变和非病变AD皮肤局部皮质类固醇therapy.Conclusions改善后，这些结果表明，受损的汗液反应在AD是由于一个异常的催汗轴突反射，这是扭转局部皮质类固醇给药。
Background Impaired sweating is thought to be a cause of barrier dysfunction in atopic dermatitis (AD).Objectives To examine the sweating function in AD in a quantitative manner.Methods We investigated the sweating response of lesional and non-lesional skin of adult patients with AD by a quantitative sudomotor axon reflex test in which the axon reflex is stimulated by acetylcholine iontophoresis. Sweat volume on the volar aspect of the forearm was measured in 18 adult patients with AD and in 40 non-atopic controls; five patients with Sjogren's syndrome were also studied as disease comparators. We also evaluated the sweating function in four AD patients after topical corticosteroid therapy. Latency time, direct (DIR) sweat volume and axon reflex-mediated indirect (AXR) sweat volume were the variables studied.Results The latency time in AD patients was significantly prolonged and AXR sweat volume significantly reduced compared with those in non-atopic control subjects. The latency time and AXR sweat volume of lesional AD skin were significantly more prolonged and reduced, respectively, than those of non-lesional skin. In contrast, the DIR sweat volume of lesional or non-lesional AD skin induced by direct stimulation with acetylcholine was only slightly reduced when compared with that in non-atopic controls. Latency time and sweat volumes of lesional and non-lesional AD skin improved after topical corticosteroid therapy.Conclusions These results suggest that the impaired sweat response in AD is attributable to an abnormal sudomotor axon reflex, which is reversed by topical corticosteroid administration.