HISTAMINE RELEASE AND ANAPHYLACTIC SHOCK IN ISOLATED LUNGS OF GUINEA‐PIGS
HISTAMINE RELEASE AND ANAPHYLACTIC SHOCK IN ISOLATED LUNGS OF GUINEA‐PIGS
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豚鼠离体肺中的组胺释放和过敏性休克
DOI：
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发表时间：
1936
期刊：
影响因子：
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通讯作者：
H. Schild
中科院分区：
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作者：
H. Schild
1. 研究了豚鼠离体林格灌注肺中组胺的释放。
2.在以下情况下在灌流液中回收组胺：(a)主动和被动致敏豚鼠过敏性休克期间； (b) 将蒸馏水灌注到正常豚鼠的肺部。
3. 在以下灌注液中未回收组胺： (a) 在强烈的平滑肌收缩期间 (BaCl2)； (b) 注射引起过敏现象的物质（琼脂、高岭土、H、OH、K、Ca 离子）后。
4.被动致敏动物在过敏性休克过程中释放的组胺量取决于致敏后的时间，并且与支气管收缩成正比。
5. 必须将比过敏性休克释放量多100倍的组胺注射到阿托品化的肺部，才能产生与过敏性休克相同的效果。
6.以抑制支气管收缩的剂量与抗原同时注射肾上腺素，减少过敏性休克中组胺的释放。它不能防止组织脱敏。
我要感谢 I. de Burgh Daly 教授对他实验室的热情接待以及无偿提供的帮助和建议。我感谢马里研究基金支付本次调查的费用。
1. The release of histamine from the isolated Ringer perfused lungs of guinea-pigs has been studied.
2. Histamine was recovered in the perfusate: (a) during anaphylactic shock in the actively and the passively sensitised guinea-pig; (b) on perfusing distilled water through the lungs of normal guinea-pigs.
3. No histamine was recovered in the perfusate: (a) during an intensive smooth muscle contraction (BaCl2); (b) after the injection of substances causing anaphylactoid phenomena (Agar, Kaolin, H, OH, K, Ca ions).
4. The quantity of histamine released during anaphylactic shock in the passively sensitised animal depends on the time after sensitisation, and it is proportional to the bronchoconstriction.
5. A quantity of histamine 100 times greater than that released during anaphylactic shock must be injected in the atropinised lungs, in order to produce an effect equal to anaphylactic shock.
6. Adrenaline injected simultaneously with the antigen in doses which inhibit bronchoconstriction, diminishes the release of histamine in anaphylactic shock. It does not prevent desensitisation of the tissue.
I wish to thank Professor I. de Burgh Daly for the hospitality of his laboratory and for help and advice freely given. I am indebted to the Moray Research Fund for defraying the expenses of this investigation.