CONGENITAL BILIARY ATRESIA AND JAUNDICE IN LAMBS AND CALVES
CONGENITAL BILIARY ATRESIA AND JAUNDICE IN LAMBS AND CALVES
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DOI：
10.1111/j.1751-0813.1990.tb07385.x
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发表时间：
1990-01-01
影响因子：
1.1
通讯作者：
UNGER, DB
中科院分区：
文献类型：
--
作者：
HARPER, P;PLANT, JW;UNGER, DB
先天性胆道闭锁和黄疸的爆发，其中约300个杂交羔羊和9个杂交小牛死亡。受影响的动物不能茁壮成长，出现黄疸和白色腹泻，并在出生4周前死亡。这次爆发和24年前发生的类似事件的一个共同特点是，怀孕早期的母羊和母牛放牧生长在Burrinjuck大坝暴露的淤泥前滩上的植物。流行病学和病理学研究结果表明，妊娠早期对胎儿的毒性损伤引起胆汁生成和胆道闭锁，导致弥漫性、亚急性至慢性胆管肝病和肝硬化。
An outbreak of congenital biliary atresia and jaundice is described, in which approximately 300 crossbred lambs and 9 crossbred calves died. The affected animals failed to thrive, developed jaundice and white scours and died without 4 weeks of birth. A common feature of this outbreak and a similar occurrence 24 years previously was the grazing of plants growing on the exposed silt foreshores of Burrinjuck Dam by ewes and cows in the early stages of pregnancy. Epidemiological and pathological findings suggestd that a toxic insult to the foetus in early gestation caused choledysgenesis and biliary atresia, leading to diffuse, subacute to chronic cholangiohepatopathy and cirrhosis.