COVID-19 pandemic, coronaviruses, and diabetes mellitus
COVID-19 pandemic, coronaviruses, and diabetes mellitus
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DOI：
10.1152/ajpendo.00124.2020
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发表时间：
2020-05-01
影响因子：
5.1
通讯作者：
Gubbi, Sriram
中科院分区：
文献类型：
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作者：
Muniyappa, Ranganath;Gubbi, Sriram
冠状病毒病（COVID-19）是一种由严重急性呼吸系统综合征冠状病毒2型（SARSCoV-2）引起的疾病，其大流行正在导致大量发病率和死亡率。年龄较大以及糖尿病、高血压和肥胖的存在显著增加了COVID-19患者住院和死亡的风险。在这方面，通过对SARS-CoV-2，中东呼吸综合征（MERS-CoV）的研究，以及目前关于SARS-CoV-2的文献，我们讨论了糖尿病调节宿主-病毒相互作用和宿主免疫反应的潜在机制。我们希望强调需要进一步研究糖尿病患者中COVID-19相关知识的差距。
The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), is causing substantial morbidity and mortality. Older age and presence of diabetes mellitus, hypertension, and obesity significantly increases the risk for hospitalization and death in COVID-19 patients. In this Perspective, informed by the studies on SARS-CoV-2, Middle East respiratory syndrome (MERS-CoV), and the current literature on SARS-CoV-2, we discuss potential mechanisms by which diabetes modulates the host-viral interactions and host-immune responses. We hope to highlight gaps in knowledge that require further studies pertinent to COVID-19 in patients with diabetes.