Identifying related cancer types based on their incidence among people with multiple cancers.
Identifying related cancer types based on their incidence among people with multiple cancers.
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DOI：
10.1186/1742-7622-3-17
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发表时间：
2006-11-08
影响因子：
2.3
通讯作者：
Gallagher RP
中科院分区：
文献类型：
--
作者：
Bajdik CD;Abanto ZU;Spinelli JJ;Brooks-Wilson A;Gallagher RP
有几个原因，一个人可能被诊断出患有一种以上的原发性癌症。这项分析的目的是确定比预期更经常发生的癌症类型的组合。先前分析中的预期值基于人群中的年龄和性别调整风险。然而，如果患有多种原发性癌症的人与患有单一原发性癌症的人有某种不同，那么预期的数字不应该基于人群中的所有诊断。在患有两种或两种以上癌症类型的人群中，特定类型被诊断的概率被确定为该癌症类型的诊断数量除以癌症诊断总数。如果两种类型的癌症彼此独立地发生，那么某人偶然患上两种癌症的概率是每种类型的个体概率的乘积。患有这两种癌症的预期人数是有风险的人数乘以每种癌症的单独概率。我们对加拿大不列颠哥伦比亚省1970年至2004年的癌症诊断记录进行了分析。在1970年至2004年期间，有28，159人记录了多种原发性癌症，其中包括1，492人诊断为3至7种癌症。在男性和女性中，食管癌与黑色素瘤和肾癌与口腔癌的组合是预期的两倍多。我们的分析表明，有几对原发性癌症可能与共同的病因有关。我们认为，当原发性癌症的多重诊断不太可能是治疗或诊断程序的结果时，我们的方法比其他方法更合适。
There are several reasons that someone might be diagnosed with more than one primary cancer. The aim of this analysis was to determine combinations of cancer types that occur more often than expected. The expected values in previous analyses are based on age-and-gender-adjusted risks in the population. However, if cancer in people with multiple primaries is somehow different than cancer in people with a single primary, then the expected numbers should not be based on all diagnoses in the population. In people with two or more cancer types, the probability that a specific type is diagnosed was determined as the number of diagnoses for that cancer type divided by the total number of cancer diagnoses. If two types of cancer occur independently of one another, then the probability that someone will develop both cancers by chance is the product of the individual probabilities for each type. The expected number of people with both cancers is the number of people at risk multiplied by the separate probabilities for each cancer. We performed the analysis on records of cancer diagnoses in British Columbia, Canada between 1970 and 2004. There were 28,159 people with records of multiple primary cancers between 1970 and 2004, including 1,492 people with between three and seven diagnoses. Among both men and women, the combinations of esophageal cancer with melanoma, and kidney cancer with oral cancer, are observed more than twice as often as expected. Our analysis suggests there are several pairs of primary cancers that might be related by a shared etiological factor. We think that our method is more appropriate than others when multiple diagnoses of primary cancer are unlikely to be the result of therapeutic or diagnostic procedures.