Maternal abuse history and reduced fetal heart rate variability: Abuse-related sleep disturbance is a mediator.
Maternal abuse history and reduced fetal heart rate variability: Abuse-related sleep disturbance is a mediator.
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DOI：
10.1017/s0954579416000997
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发表时间：
2017-08
影响因子：
3.3
通讯作者：
Monk C
中科院分区：
文献类型：
--
作者：
Gustafsson H;Doyle C;Gilchrist M;Werner E;Monk C
儿童虐待的后果是深远而持久的。虐待的受害者不仅在童年时遭受痛苦，而且越来越多的证据表明，虐待史使下一代面临严重精神病理学的风险。研究发现出生后因素会影响这种创伤的代际传播。然而，新出现的证据表明，部分风险可能在出生前传播，通过子宫内环境中与虐待相关的变化而传播，而这些变化在很大程度上尚未确定。迄今为止，还没有研究直接评估孕妇的虐待史对胎儿神经行为发育的影响，也没有将创伤相关的睡眠质量差视为反映既定生理失调的中介因素。目前的研究利用 262 名怀孕青少年（14-19 岁）（儿童期虐待风险较高的人群）的数据，检查了母亲情绪虐待史和睡眠质量与妊娠晚期胎儿静息心率变异性（副交感神经系统功能指数）的关系。结果表明，母亲的情绪虐待史通过虐待相关的睡眠障碍与较低的胎儿心率变异性间接相关。这些数据证明了母亲虐待史与胎儿发育之间的关联，表明至少部分风险的代际传播发生在怀孕期间。
The consequences of childhood maltreatment are profound and long lasting. Not only does the victim of abuse suffer as a child, but there is mounting evidence that a history of maltreatment places the next generation at risk for significant psychopathology. Research identifies postnatal factors as affecting this intergenerational transmission of trauma. However, emerging evidence suggests that part of this risk may be transmitted before birth, passed on via abuse-related alterations in the in utero environment that are as yet largely unidentified. To date, no study has directly assessed the influence of pregnant women’s abuse history on fetal neurobehavioral development, nor considered trauma-associated poor sleep quality as a mediator reflecting established physiological dysregulation. Using data from 262 pregnant adolescents (ages 14–19), a population at elevated risk for childhood maltreatment, the current study examined maternal emotional abuse history and sleep quality in relation to third-trimester fetal resting heart rate variability, an index of parasympathetic nervous system functioning. The results indicate that maternal emotional abuse history is indirectly associated with lower fetal heart rate variability via abuse-related sleep disturbances. These data demonstrate an association between maternal abuse histories and fetal development, showing that at least part of the intergenerational transmission of risk occurs during pregnancy.