Biological markers for anxiety disorders, OCD and PTSD - a consensus statement. Part I: Neuroimaging and genetics
Biological markers for anxiety disorders, OCD and PTSD - a consensus statement. Part I: Neuroimaging and genetics
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DOI：
10.1080/15622975.2016.1181783
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发表时间：
2016-08-01
影响因子：
3.1
通讯作者：
Riederer, Peter
中科院分区：
文献类型：
--
作者：
Bandelow, Borwin;Baldwin, David;Riederer, Peter
目的：生物标志物是指某些疾病或综合征所特有的解剖、生化或生理特征。本文的目的是总结焦虑症、强迫症（OCD）和创伤后应激障碍（PTSD）的生物标志物的现有知识。生物标志物研究的发现由该领域的国际专家组成的工作组进行了审查，由世界生物精神病学学会联合会生物标记物工作队和欧洲精神病学学会的成员组成，结果：本文（第一部分）总结了神经影像学研究中潜在生物标志物的发现，包括结构性脑形态学，功能性磁共振成像和测量代谢变化的技术，包括正电子发射断层扫描等。此外，本综述报告的临床和分子遗传学的结果，家庭，双胞胎，连锁，协会和全基因组关联的研究。第二部分的审查集中在神经化学，神经生理学和neurocognition.Conclusions：虽然目前，没有一个假定的生物标志物是足够的和具体的诊断工具，丰富的高质量的研究积累，将提高我们的理解焦虑症，强迫症和创伤后应激障碍的神经生物学原因。
Objectives: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD).Methods: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network.Results: The present article (Part I) summarises findings on potential biomarkers in neuroimaging studies, including structural brain morphology, functional magnetic resonance imaging and techniques for measuring metabolic changes, including positron emission tomography and others. Furthermore, this review reports on the clinical and molecular genetic findings of family, twin, linkage, association and genome-wide association studies. Part II of the review focuses on neurochemistry, neurophysiology and neurocognition.Conclusions: Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high-quality research has accumulated that will improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.