Better prognosis of hepatic resection combined with antiviral therapy for HBV-related hepatocellular carcinoma with BCLC Stage B/C.
Better prognosis of hepatic resection combined with antiviral therapy for HBV-related hepatocellular carcinoma with BCLC Stage B/C.
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DOI：
10.1016/j.asjsur.2016.03.001
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发表时间：
2017-11
影响因子：
3.5
通讯作者：
Qinfeng Wei;Huan Tian;Huan Luo;Yingcai Zhang;Yinan Deng;Jia Yao;Hua Li;Guihua Chen;Yang Yang-Yang
中科院分区：
文献类型：
--
作者：
Qinfeng Wei;Huan Tian;Huan Luo;Yingcai Zhang;Yinan Deng;Jia Yao;Hua Li;Guihua Chen;Yang Yang-Yang
BackgroundWhether hepatic resection (HR) could be performed for patients with Barcelona Clinic Liver Cancer (BCLC) B/C stage hepatocellular carcinoma (HCC) is controversial, and the safety and clinical value of HR combined with antiviral therapy for hepatitis B virus (HBV)-related HCC with BCLC-B/C stage remain to be investigated.MethodsWe retrospectively evaluated 126 patients with BCLC stage B/C HCC who underwent HR. These patients were divided into the antiviral group (Group A,n= 86) and the control group (Group B,n= 40). The operative indications and prognosis of 126 patients were analyzed.ResultsThe 1-year, 3-year, and 5-year disease-free survival (DFS) rates for Group A and Group B were 55.4%, 36.1%, 33.7% and 53.8%, 28.2%, 23.1%, respectively. The corresponding overall survival (OS) rates for the two groups were 89.2%, 61.4%, 45.8% and 82.1%, 48.7%, 33.3%, respectively. The DFS and OS for Group A were better than for Group B (p= 0.013, andp= 0.038, respectively). Antiviral therapy was an independent protective factor of late tumor recurrence [hazard ratio (HR) = 0.391, 95% confidence interval (CI): 0.190–0.806,p= 0.011] but not of early tumor recurrence.ConclusionIt is safe and feasible to perform HR combined with antiviral therapy for HBV-related HCC with BCLC stage B/C.
