GROWTH OF THE RAT PROSTATE-GLAND IS FACILITATED BY THE AUTONOMIC NERVOUS-SYSTEM
GROWTH OF THE RAT PROSTATE-GLAND IS FACILITATED BY THE AUTONOMIC NERVOUS-SYSTEM
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DOI：
10.1095/biolreprod51.1.99
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发表时间：
1994-07-01
影响因子：
3.6
通讯作者：
MCKENNA, KE
中科院分区：
文献类型：
--
作者：
MCVARY, KT;RAZZAQ, A;MCKENNA, KE
许多因素与前列腺生长的发展有关：雄激素、生长因子和基质-上皮相互作用。本研究探讨了自主神经系统的交感神经和副交感神经分支在控制大鼠前列腺生长和萎缩的不同方面的作用。单侧交感神经切除术会导致病变侧腹侧前列腺重量、DNA 和蛋白质含量减少。单侧副交感神经切除术会导致完整侧腹侧前列腺重量、DNA 和蛋白质含量增加。交感神经切除术和副交感神经切除术的单独效果在多种神经操作组合中得以维持。根据组织去甲肾上腺素水平评估，操作后 60 天尚未出现显着的神经支配重新支配。自主神经系统对腹侧前列腺的生长和维持似乎存在不同的影响。对侧增生和同侧萎缩的机制对于理解人类前列腺异常生长具有潜在意义。
Many factors are implicated in the development of prostatic growth: androgens, growth factors, and stromo-epithelial interaction. This study examines the role of the sympathetic and parasympathetic branches of the autonomic nervous system control of different aspects of rat prostate growth and atrophy. Unilateral sympathectomy leads to decreases in ventral prostate weight, DNA, and protein content in the lesioned side. Unilateral parasympathectomy leads to increases in ventral prostate weight, DNA, and protein content in the intact side. The separate effects of sympathectomy and parasympathectomy are maintained across a diverse combination of neural manipulations. Significant re-innervation does not occur by 60 days after manipulation as assessed by tissue norepinephrine levels. There appears to be a differential effect of the autonomic nervous system on growth and maintenance of the ventral prostate. The mechanism of contralateral hyperplasia and ipsilateral atrophy has potential significance in understanding human abnormal prostate growth.