Role of Nrf2 in cell senescence regulation
Role of Nrf2 in cell senescence regulation
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DOI：
10.1007/s11010-020-03901-9
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发表时间：
2020-09-11
影响因子：
4.3
通讯作者：
Xiao，Jian-Hui
中科院分区：
文献类型：
--
作者：
Yuan，Huan;Xu，Yan;Xiao，Jian-Hui
核因子E2相关因子2（Nuclear factor-E2-related factor 2，Nrf 2）是维持细胞氧化还原平衡和信号转导的关键转录因子，在减少细胞内氧化应激损伤、延缓细胞衰老和预防衰老相关疾病中发挥重要作用。然而，已经表明Nrf 2的水平随着年龄的增长而降低，并且Nrf 2基因的沉默与早衰的诱导有关。因此，大量的研究人员集中在阐明Nrf 2在防止细胞衰老中的调节机制。Nrf 2在细胞衰老过程中的这种复杂的调节机制涉及多个信号分子的协调调节。本文综述了Nrf 2的功能及其与细胞衰老途径的关系，重点介绍了Nrf 2在细胞衰老过程中的调控机制的研究进展。此外，这里收集的信息可以为进一步研究Nrf 2提供见解，特别是其在细胞衰老过程中的调控机制。
Nuclear factor-E2-related factor 2 (Nrf2) is a key transcription factor known to be involved in maintaining cell redox balance and signal transduction and plays central role in reducing intracellular oxidative stress damage, delaying cell senescence and preventing age-related diseases. However, it has been shown that the level of Nrf2 decreases with age and that the silencing of theNrf2gene is associated with the induction of premature senescence. Therefore, a plethora of researchers have focused on elucidating the regulatory mechanism of Nrf2 in the prevention of cell senescence. This complex regulatory mechanism of Nrf2 in the cell senescence process involves coordinated regulation of multiple signaling molecules. After summarizing the function of Nrf2 and its relationship with cell senescence pathway, this review focuses on the recent advances and progress made in elucidating the regulatory mechanism of Nrf2 in the cell senescence process. Additionally, the information collected here may provide insights for further research on Nrf2, in particular, on its regulatory mechanism in the cell senescence process.