Depressive reactions to lung cancer are common and often followed by a poor outcome
Depressive reactions to lung cancer are common and often followed by a poor outcome
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DOI：
10.1183/09031936.98.11010173
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发表时间：
1998-01-01
影响因子：
24.3
通讯作者：
Buccheri, G
中科院分区：
文献类型：
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作者：
Buccheri, G
在包括肺癌在内的多种人类恶性肿瘤中，生活质量（QOL）影响患者的临床结局。然而，许多QOL维度受身体状况的影响。目前的研究是为了描述抑郁的作用，抑郁是一种不一定受躯体因素影响的精神状态。所有新诊断的肺癌患者都接受了W.W.K.提出的抑郁自评量表（SDS）。Zung. 133名患者能够并愿意完成问卷调查，计算抑郁指数，如最初所述。95例完成问卷20个项目的患者中，53例SDS指数小于或等于50（无抑郁），42例为中度或重度抑郁（SDS指数>50）。抑郁症患者的生存率明显较低（p=0.048）。不同的SDS分量表与生存相关，无论是单因素还是多因素分析，SDS项目19，“我觉得如果我死了，别人会更好”，是最重要的一个。仅使用SDS数据构建的多变量生存模型的总体卡方值为29.78，p值为0.00023。基于这一证据，似乎患者的抑郁与预后之间确实存在关系，至少在肺癌中是这样。需要进一步的研究来阐明抑郁症在更具体（和同质）的亚组患者中的预后作用。
In diverse human malignancies, including lung cancer, quality of life (QOL) affects the clinical outcome of patients, Many QOL dimensions, however, are influenced by physical status. The current study was undertaken to delineate the role of depression, a state of mind not necessarily influenced by somatic factors.All patients, seen for a newly diagnosed carcinoma of the lung, received a copy of the Self-rating Depression Scale (SDS) proposed by W.W.K. Zung. One hundred and thirty three patients were able and willing to complete the questionnaire, A depression index was calculated, as originally described. Nineteen other prognostically important variables were recorded and available for evaluation.Among the 95 patients who completed all 20 items included in the questionnaire, 53 had an SDS index less than or equal to 50 (no depression), while 42 were moderately or severely depressed (SDS index >50). The survival of depressed patients was significantly lower (p=0.048). Diverse SDS subscales were associated with survival, in either univariate or multivariate analysis, SDS item 19, "I feel that others would be better off if I were dead", emerged as the most significant one. A multivariate model of survival, constructed using only SDS data, had a global Chi-squared value of 29.78, and a p-value of 0.00023.Based on this evidence, it appears that a relationship does exist between patients' depression and prognosis, at least in lung cancer. Further studies are needed to clarify the prognostic effect of depression in more specific (and homogeneous) subgroups of patients.