Cutaneous Myelofibrosis With JAK2 V617F Mutation: Metastasis, Not Merely Extramedullary Hematopoiesis!
Cutaneous Myelofibrosis With JAK2 V617F Mutation: Metastasis, Not Merely Extramedullary Hematopoiesis!
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DOI：
10.1097/dad.0b013e3181d3ca2f
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发表时间：
2010-10-01
影响因子：
1.1
通讯作者：
Caughron, Samuel K.
中科院分区：
文献类型：
--
作者：
Fraga, Garth R.;Caughron, Samuel K.
原发性骨髓纤维化（PMF）是一种骨髓增生性肿瘤。有31例报告的PMF累及皮肤病例，其中大多数被描述为“髓外造血”。“我们报告了一个由PMF累及皮肤的新病例，并证明了皮肤病变中Janus激酶2基因的突变。髓外骨髓纤维化最好被认为是一种转移现象。髓外造血等病例的报告可能会引起与反应性髓外造血形式的混淆。
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm. There are 31 reported cases of cutaneous involvement by PMF, most of which have been described as "extramedullary hematopoiesis.'' We report a new case of cutaneous involvement by PMF and demonstrate mutation of the Janus kinase 2 gene in the cutaneous lesions. Extramedullary myelofibrosis is best considered a metastatic phenomenon. Reporting such cases as extramedullary hematopoiesis may cause confusion with reactive forms of extramedullary hematopoiesis.