Catalytic asymmetric Michael reaction under phase-transfer catalysis: Construction of chiral tetrasubstituted carbon and its application to the synthesis of a chiral pyrrolidone
Catalytic asymmetric Michael reaction under phase-transfer catalysis: Construction of chiral tetrasubstituted carbon and its application to the synthesis of a chiral pyrrolidone
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DOI：
10.3987/com-05-s(t)41
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发表时间：
2006-02-01
期刊：
影响因子：
0.6
通讯作者：
Nishida, A
中科院分区：
文献类型：
--
作者：
Arai, S;Takahashi, F;Nishida, A
研究了以D-2-对称铵盐促进的Schiff碱为相转移催化剂的不对称Michael反应。甘氨酸席夫碱(1a)与甘氨酸席夫碱(1a)反应生成的Michael加合物具有高达91%的ee，四取代碳也是用丙氨酸席夫碱(3a)与高达63%ee的丙氨酸席夫碱(3a)构建的。
A catalytic asymmetric Michael reaction using Schiff bases promoted by D-2-symmetrical ammonium salts as phase-transfer catalysts is described. The reaction of glycine Schiff base (1a) gave the Michael adduct with up to 91% ee and tetrasubstituted carbons was also constructed using alanine Schiff base (3a) with up to 63% ee.