A single factor dominates the behavior of rhythmic genes in mouse organs
A single factor dominates the behavior of rhythmic genes in mouse organs
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单一因素主导小鼠器官节律基因的行为
DOI：
10.1186/s12864-019-6255-3
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发表时间：
2019-11-20
期刊：
影响因子：
4.4
通讯作者：
Wang, Guang-Zhong
中科院分区：
文献类型：
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作者：
Cheng, Yang;Chi, Yuhao;Wang, Guang-Zhong
昼夜节律是一个复杂的多尺度生物振荡器，受机体内外环境的共同调节。在分子水平上，成千上万的基因表现出节律性转录，这是器官和物种特异性的，但是否有一些共同因素可以潜在地解释它们在不同器官中的节律性仍然是一个谜。在这项研究中，我们通过分析12个小鼠器官的转录组数据来确定这些主要的影响因素来解决这个问题。结果我们发现小鼠器官中昼夜节律基因的转录水平与节律幅度之间存在很强的正相关关系。此外，转录水平可以解释超过70%的幅度变化。此外，节律基因的功能和组织特异性并不是振幅的强预测因子，节律基因的表达水平与转录相关的能量消耗有关。结论表达水平是影响节律基因在小鼠器官中行为的单一主要因素。这个单一的决定因素暗示了韵律表达本身在转录系统设计中的重要性。因此，高表达基因的节律性调控可以有效降低转录的能量成本，促进整个遗传系统的长期适应性进化。
BackgroundCircadian rhythm, regulated by both internal and external environment of the body, is a multi-scale biological oscillator of great complexity. On the molecular level, thousands of genes exhibit rhythmic transcription, which is both organ- and species-specific, but it remains a mystery whether some common factors could potentially explain their rhythmicity in different organs. In this study we address this question by analyzing the transcriptome data in 12 mouse organs to determine such major impacting factors.ResultsWe found a strong positive correlation between the transcriptional level and rhythmic amplitude of circadian rhythmic genes in mouse organs. Further, transcriptional level could explain over 70% of the variation in amplitude. In addition, the functionality and tissue specificity were not strong predictors of amplitude, and the expression level of rhythmic genes was linked to the energy consumption associated with transcription.ConclusionExpression level is a single major factor impacts the behavior of rhythmic genes in mouse organs. This single determinant implicates the importance of rhythmic expression itself on the design of the transcriptional system. So, rhythmic regulation of highly expressed genes can effectively reduce the energetic cost of transcription, facilitating the long-term adaptive evolution of the entire genetic system.