The Interactive Effects of Cerebral Perfusion and Depression on Cognitive Function in Older Adults With Heart Failure
The Interactive Effects of Cerebral Perfusion and Depression on Cognitive Function in Older Adults With Heart Failure
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DOI：
10.1097/psy.0b013e31829f91da
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发表时间：
2013-09-01
影响因子：
3.3
通讯作者：
Gunstad, John
中科院分区：
文献类型：
--
作者：
Alosco, Michael L.;Spitznagel, Mary Beth;Gunstad, John
目的：抑郁症在心力衰竭（HF）患者中很常见，并且与该人群的认知功能障碍有关。这种关系的机制尚不清楚，目前的研究考察了脑灌注是否能调节心衰患者抑郁症状和认知障碍之间的关联。方法：HF患者（n = 89，平均[标准差]年龄= 67.61[11.78]岁）完成神经心理测试和阻抗心动图。使用贝克抑郁量表II评估抑郁症状，并使用经颅多普勒量化脑灌注。结果：在未调整的模型中，抑郁与评估注意力/执行功能（r = -0.28）、语言（r = -0.0.30）和运动功能（r = -0.28）的任务表现下降有关（p值）
Objective: Depression is common among persons with heart failure (HF) and has been linked to cognitive impairment in this population. The mechanisms of this relationship are unclear, and the current study examined whether cerebral perfusion moderates the association between depressive symptoms and cognitive impairment in patients with HF. Methods: Persons with HF (n = 89; mean [standard deviation] age = 67.61 [11.78] years) completed neuropsychological testing and impedance cardiography. Depressive symptoms were assessed using the Beck Depression Inventory II, and transcranial Doppler was used to quantify cerebral perfusion. Results: Depression was associated with reduced performance on tasks assessing attention/executive function (r = -0.28), language (r = -0.0.30), and motor function (r = -0.28) in unadjusted models (p values