Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects
Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects
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DOI：
10.1007/s00417-015-2935-0
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发表时间：
2015-04-01
影响因子：
2.7
通讯作者：
Aung, Tin
中科院分区：
文献类型：
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作者：
Ho, Henrietta;Ozaki, Mineo;Aung, Tin
使用眼前节光学相干断层扫描（ASOCT）比较中国和日本闭角受试者的眼前段参数。招募了142名日本和192名原发性闭角（PAC）或原发性闭角型青光眼（PACG）受试者。所有参与者均接受了 A 扫描生物测量和 ASOCT 成像（Visante，Carl Zeiss Meditec，都柏林，加利福尼亚州，美国）。使用定制软件测量水平 ASOCT 扫描中的 ASOCT 参数。对参数进行比较，并进行多变量分析以确定距巩膜骨刺 750 μm 处的开角距离 (AOD750) 的预测因子。通过根据年龄、性别、球当量、瞳孔直径和眼轴长度进行调整的多元线性回归评估的种族差异显示，日本闭角受试者的前房深度明显较浅 (ACD;beta = -0.3, p < 0.001)、较小的前房面积 (ACA; beta = -0.21, p = 0.02) 和体积 (ACV; beta = -0.19, p = 0.01)、较大的晶状体穹窿 (LV, beta = 0.3, p < 0.001)、晶状体厚度 (LT; beta = 0.48, p < 0.001)、较大的虹膜面积 (IArea; beta = 0.19，p = 0.01），以及更弯曲的虹膜（ICurv；beta = 0.16，p = 0.04）。在日语中，AOD750 的重要决定因素是虹膜厚度（IT；beta = -0.21，p = 0.04）、ICurv（beta = -0.17，p = 0.04）、瞳孔直径（PD；beta = -0.34，p = 0.001）和 ACV（beta = 0.32，p < 0.001）；中国人的IT（beta = -0.25，p = 0.001）、ACV（beta = 0.37，p < 0.001）、PD（beta = -0.26，p = 0.001）和LV（beta = -0.18，p = 0.03）。与中国人相比，日本闭角眼的眼前节更小、更拥挤，镜片更厚。 ACV、IT 和 PD 是两场比赛中角度宽度的重要因素。这些结果表明闭角机制可能存在种族差异。
To compare anterior segment parameters in Chinese and Japanese subjects with angle closure using anterior segment optical coherence tomography (ASOCT).One hundred and forty-two Japanese and one hundred and ninety-two Chinese subjects with primary angle closure (PAC) or primary angle-closure glaucoma (PACG) were recruited. All participants underwent A-scan biometry and ASOCT imaging (Visante, Carl Zeiss Meditec, Dublin, CA, USA). Customized software was used to measure ASOCT parameters in horizontal ASOCT scans. The parameters were compared, and multivariate analysis was performed to determine predictors of angle opening distance at 750 mu m from the scleral spur (AOD750).Ethnic difference evaluated by multiple linear regression adjusted for age, gender, spherical equivalent, pupil diameter, and axial length showed that Japanese angle-closure subjects had significantly shallower anterior chamber depth (ACD;beta = -0.3, p < 0.001), smaller anterior chamber area (ACA; beta = -0.21, p = 0.02) and volume (ACV; beta = -0.19, p = 0.01), greater lens vault (LV, beta = 0.3, p < 0.001), lens thickness (LT; beta = 0.48, p < 0.001), greater iris area (IArea; beta = 0.19, p = 0.01), and more curved iris (ICurv; beta = 0.16, p = 0.04). The significant determinants of AOD750 were iris thickness (IT; beta = -0.21, p = 0.04), ICurv (beta = -0.17, p = 0.04), pupil diameter (PD; beta = -0.34, p = 0.001) and ACV (beta = 0.32, p < 0.001) in Japanese; and IT (beta = -0.25, p = 0.001), ACV (beta = 0.37, p < 0.001), PD (beta = -0.26, p = 0.001), and LV (beta = -0.18, p = 0.03) in Chinese.Compared to Chinese, Japanese angle-closure eyes have smaller and more crowded anterior segment with thicker lenses. ACV, IT, and PD are important factors for angle width in both races. These results suggest possible ethnic differences in angle-closure mechanism(s).