Verapamil suppresses atherosclerosis in cholesterol-fed rabbits.
Verapamil suppresses atherosclerosis in cholesterol-fed rabbits.
复制标题
维拉帕米可抑制胆固醇喂养兔子的动脉粥样硬化。
DOI：
10.1016/s0735-1097(83)80049-7
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发表时间：
1983
影响因子：
24
通讯作者：
Havel,RJ
中科院分区：
文献类型：
--
作者：
Rouleau,JL;Parmley,WW;Stevens,J;Wikman-Coffelt,J;Sievers,R;Mahley,RW;Havel,RJ
维拉帕米（一种降低细胞内钙浓度的药物）对动脉粥样硬化形成的影响是在喂食富含胆固醇的饮食10周的兔子中进行的。 10只兔子口服维拉帕米，每天8毫克/公斤； 8 名患者接受相同的口服剂量和每日 0.5 mg/kg 的皮下注射； 9 名患者接受每日 35 毫克/公斤的口服镧，9 名患者为对照组。在 10 周期间，所有组的平均血清胆固醇水平均大于 1,500 mg/dl（正常 = 90 ± 63 mg/dl）。实验结束时，取出主动脉，打开并用苏丹 IV 进行脂质染色。通过面积测量法测定动脉粥样硬化的程度。与对照组（73±24%）相比，口服和肠外维拉帕米组的动脉粥样硬化明显减少（总内膜面积的25±26%；平均值±标准差）。口服维拉帕米 (51 ± 22%) 和镧 (59 ± 31) 减少动脉粥样硬化的效果没有统计学意义。口服和肠胃外维拉帕米治疗组的离体右心室乳头肌收缩指数（最大长度[Lmax]时产生的张力[Lmax]和最大缩短速度[Vmax]）有所降低，但其他组则没有。结论是，维拉帕米可抑制饲喂富含胆固醇饮食的兔子的动脉粥样硬化的发展。
The effect of verapamil, a drug that reduces the concentration of intracellular calcium, on atherogenesis was evaluated in rabbits fed a cholesterol-rich diet for 10 weeks. Ten rabbits received oral verapamil, 8 mg/kg daily; eight received the same oral dose and 0.5 mg/kg daily subcutaneously; nine received oral lanthanum, 35 mg/kg daily, and nine were controls. Over the 10 week period, all groups had average serum cholesterol levels greater than 1,500 mg/dl (normal = 90 ± 63 mg/dl). At the end of the experiment, the aortas were removed, opened and stained for lipid with Sudan IV. The extent of atherosclerosis was determined by planimetry. The group receiving oral and parenteral verapamil had significantly less atherosclerosis (25 ± 26% of total intimai area; mean ± standard deviation), as compared with the controls (73 ± 24%). Reduction of atherosclerosis with oral verapamil (51 ± 22%) and lanthanum (59 ± 31) was not statistically significant. Indexes of contractility in isolated right ventricular papillary muscles (developed tension at maximal length [Lmax] and maximal velocity of shortening [Vmax]) were reduced in the group treated with oral and parenteral verapamil, but not in the others. It is concluded that verapamil suppresses the development of atherosclerosis in rabbits fed a cholesterol-rich diet.