High sensitivity and specificity in proposed clinical diagnostic criteria for anti-N-methyl-D-aspartate receptor encephalitis
High sensitivity and specificity in proposed clinical diagnostic criteria for anti-N-methyl-D-aspartate receptor encephalitis
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DOI：
10.1111/dmcn.13579
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发表时间：
2017-12-01
影响因子：
3.8
通讯作者：
Dale, Russell C.
中科院分区：
文献类型：
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作者：
Ho, Alvin C. C.;Mohammad, Shekeeb S.;Dale, Russell C.
目的确定儿科患者抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎的拟议临床诊断标准的有效性方法格劳斯et al.（2016）提出的抗NMDAR脑炎的诊断标准使用临床特征和常规检查，以促进抗体状态可用之前的早期免疫治疗。如果患者在3个月内出现6个症状组中的4个，同时至少有1项检查异常（脑电图/脑脊液）并合理排除其他疾病，则符合标准。我们使用一个回顾性队列的小儿脑炎患者评价标准的有效性。29例抗NMDAR脑炎和74例对照儿童脑炎被included.RESULTS正如预期的那样，符合临床标准的抗NMDAR脑炎患者的百分比随着时间的推移而增加。在住院期间，大多数抗NMDAR脑炎患者（26/29，90%）符合标准，显着高于对照组（3/74，4%）（p
AIM To determine the validity of the proposed clinical diagnostic criteria for anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in paediatric patients.METHOD The diagnostic criteria for anti-NMDAR encephalitis proposed by Graus et al. (2016) use clinical features and conventional investigations to facilitate early immunotherapy before antibody status is available. The criteria are satisfied if patients develop four out of six symptom groups within 3 months, together with at least one abnormal investigation (electroencephalography/cerebrospinal fluid) and reasonable exclusion of other disorders. We evaluated the validity of the criteria using a retrospective cohort of paediatric patients with encephalitis. Twenty-nine patients with anti-NMDAR encephalitis and 74 comparison children with encephalitis were included.RESULTS As expected, the percentage of patients with anti-NMDAR encephalitis who fulfilled the clinical criteria increased over time. During the hospital inpatient admission, most patients (26/29, 90%) with anti-NMDAR encephalitis fulfilled the criteria, significantly more than the comparison group (3/74, 4%) (p